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Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer
Gang Xin, Yao Chen, Paytsar Topchyan, Moujtaba Y. Kasmani, Robert Burns, Peter J. Volberding, Xiaopeng Wu, Alexandra Cohn, Yiliang Chen, Chien-Wei Lin, Ping-Chih Ho, Roy Silverstein, Michael B. Dwinell, Weiguo Cui

Cancer Immunology Research Apr 2021, 9 (4) 454-469; DOI: 10.1158/2326-6066.CIR-20-0433
Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8⁺ T Cells
Adam N.R. Cartwright, Shengbao Suo, Soumya Badrinath, Sushil Kumar, Johannes Melms, Adrienne Luoma, Archis Bagati, Assieh Saadatpour, Benjamin Izar, Guo-Cheng Yuan, Kai W. Wucherpfennig

Cancer Immunology Research Apr 2021, 9 (4) 470-485; DOI: 10.1158/2326-6066.CIR-20-0085
Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling
Elisa Landoni, Giovanni Fucá, Jian Wang, Venkat R. Chirasani, Zhiyuan Yao, Elena Dukhovlinova, Soldano Ferrone, Barbara Savoldo, Lee K. Hong, Peishun Shou, Silvia Musio, Francesco Padelli, Gaetano Finocchiaro, Miriam Droste, Brian Kuhlman, Abdijapar Shamshiev, Serena Pellegatta, Nikolay V. Dokholyan, Gianpietro Dotti

Cancer Immunology Research Apr 2021, 9 (4) 441-453; DOI: 10.1158/2326-6066.CIR-20-0451
DGKA Mediates Resistance to PD-1 Blockade
Lingyi Fu, Sen Li, WeiWei Xiao, Kuai Yu, Shuo Li, Sujing Yuan, Jianfei Shen, Xingjun Dong, Ziqian Fang, Jianeng Zhang, Siyu Chen, Wende Li, Hua You, Xiaojun Xia, Tiebang Kang, Jing Tan, Gong Chen, An-Kui Yang, YuanHong Gao, Penghui Zhou

Cancer Immunology Research Apr 2021, 9 (4) 371-385; DOI: 10.1158/2326-6066.CIR-20-0216
Enhancing the Generation of Eomes^hi CD8⁺ T Cells Augments the Efficacy of OX40- and CTLA-4–Targeted Immunotherapy
Dana A. Emerson, Annah S. Rolig, William L. Redmond

Cancer Immunology Research Apr 2021, 9 (4) 430-440; DOI: 10.1158/2326-6066.CIR-20-0338
Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Reham Ajina, Zoe X. Malchiodi, Allison A. Fitzgerald, Annie Zuo, Shangzi Wang, Maha Moussa, Connor J. Cooper, Yue Shen, Quentin R. Johnson, Jerry M. Parks, Jeremy C. Smith, Marta Catalfamo, Elana J. Fertig, Sandra A. Jablonski, Louis M. Weiner

Cancer Immunology Research Apr 2021, 9 (4) 386-400; DOI: 10.1158/2326-6066.CIR-20-0272
Modified Hypoxia-Inducible Factor Expression in CD8⁺ T Cells Increases Antitumor Efficacy
Pedro Veliça, Pedro P. Cunha, Nikola Vojnovic, Iosifina Petrina Foskolou, David Bargiela, Milos Gojkovic, Helene Rundqvist, Randall S. Johnson

Cancer Immunology Research Apr 2021, 9 (4) 401-414; DOI: 10.1158/2326-6066.CIR-20-0561
Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth
Mark D. Badeaux, Annah S. Rolig, Giulia Agnello, Danlee Enzler, Melissa J. Kasiewicz, Leslie Priddy, Jason F. Wiggins, Alexander Muir, Mark R. Sullivan, Jessica Van Cleef, Christopher Daige, Matthew G. Vander Heiden, Venkatesh Rajamanickam, James E. Wooldridge, William L. Redmond, Scott W. Rowlinson

Cancer Immunology Research Apr 2021, 9 (4) 415-429; DOI: 10.1158/2326-6066.CIR-20-0317
A Machine Learning Approach Yields a Multiparameter Prognostic Marker in Liver Cancer
Xiaoli Liu, Jilin Lu, Guanxiong Zhang, Junyan Han, Wei Zhou, Huan Chen, Henghui Zhang, Zhiyun Yang

Cancer Immunology Research Mar 2021, 9 (3) 337-347; DOI: 10.1158/2326-6066.CIR-20-0616
The IKZF1–IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages
Dimitrios Mougiakakos, Christian Bach, Martin Böttcher, Fabian Beier, Linda Röhner, Andrej Stoll, Michael Rehli, Claudia Gebhard, Christopher Lischer, Martin Eberhardt, Julio Vera, Maike Büttner-Herold, Katrin Bitterer, Heidi Balzer, Magdalena Leffler, Simon Jitschin, Michael Hundemer, Mohamed H.S. Awwad, Martin Busch, Steffen Stenger, Simon Völkl, Christian Schütz, Jan Krönke, Andreas Mackensen, Heiko Bruns

Cancer Immunology Research Mar 2021, 9 (3) 265-278; DOI: 10.1158/2326-6066.CIR-20-0555

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