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Cancer Immunology Research
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The Tumor Microenvironment Impairs Th1 IFNγ Secretion through Alternative Splicing Modifications of Irf1 Pre-mRNA

Antoine Bernard, Christophe Hibos, Corentin Richard, Etienne Viltard, Sandy Chevrier, Sophie Lemoine, Joséphine Melin, Etienne Humblin, Romain Mary, Théo Accogli, Fanny Chalmin, Mélanie Bruchard, Paul Peixoto, Eric Hervouet, Lionel Apetoh, François Ghiringhelli, Frédérique Végran and Romain Boidot
Antoine Bernard
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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Christophe Hibos
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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  • ORCID record for Christophe Hibos
Corentin Richard
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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Etienne Viltard
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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Sandy Chevrier
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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Sophie Lemoine
4Genomic Platform, Institut de Biologie de l'ENS, Paris, France.
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Joséphine Melin
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
5LipSTIC LabEx, Dijon, Burgundy, France.
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Etienne Humblin
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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Romain Mary
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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Théo Accogli
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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Fanny Chalmin
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
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Mélanie Bruchard
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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Paul Peixoto
6INSERM UMR1098 “Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique,” Besançon, France.
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Eric Hervouet
6INSERM UMR1098 “Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique,” Besançon, France.
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  • ORCID record for Eric Hervouet
Lionel Apetoh
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
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François Ghiringhelli
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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Frédérique Végran
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
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  • For correspondence: rboidot@cgfl.fr frederique.vegran@inserm.fr
Romain Boidot
1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
3Centre Georges François Leclerc, Dijon, Burgundy, France.
7UMR CNRS 6302, Dijon, Burgundy, France.
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  • ORCID record for Romain Boidot
  • For correspondence: rboidot@cgfl.fr frederique.vegran@inserm.fr
DOI: 10.1158/2326-6066.CIR-19-0679 Published March 2021
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Article Information

Volume 9, Issue 3, pp. 324-336

DOI 
https://doi.org/10.1158/2326-6066.CIR-19-0679
PubMed 
33419764

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received September 4, 2019
  • Revision received June 26, 2020
  • Accepted January 6, 2021
  • Published first January 8, 2021.

Article Versions

  • Previous version (January 8, 2021 - 05:54).
  • Previous version (February 5, 2021 - 05:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2021 American Association for Cancer Research.

Author Information

  1. Antoine Bernard1,2,3,
  2. Christophe Hibos1,2,
  3. Corentin Richard2,3,
  4. Etienne Viltard1,2,
  5. Sandy Chevrier3,
  6. Sophie Lemoine4,
  7. Joséphine Melin2,5,
  8. Etienne Humblin1,2,
  9. Romain Mary1,2,
  10. Théo Accogli1,2,
  11. Fanny Chalmin1,
  12. Mélanie Bruchard1,2,3,
  13. Paul Peixoto6,
  14. Eric Hervouet6,
  15. Lionel Apetoh1,2,
  16. François Ghiringhelli1,2,3,
  17. Frédérique Végran1,2,3,#,*, and
  18. Romain Boidot1,2,3,7,#,*
  1. 1CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France.
  2. 2Faculté des Sciences de Santé, Université Bourgogne Franche-Comté, Dijon, Burgundy, France.
  3. 3Centre Georges François Leclerc, Dijon, Burgundy, France.
  4. 4Genomic Platform, Institut de Biologie de l'ENS, Paris, France.
  5. 5LipSTIC LabEx, Dijon, Burgundy, France.
  6. 6INSERM UMR1098 “Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique,” Besançon, France.
  7. 7UMR CNRS 6302, Dijon, Burgundy, France.
  1. ↵*Corresponding Authors:
    Romain Boidot, Georges-Francois Leclerc Cancer Center – UNICANCER, Unit of Molecular Biology, 1, rue Pr Marion, Dijon, Burgundy 21079, France. Phone: 333-8073-7767; Fax: 333-8073-7782; E-mail: rboidot{at}cgfl.fr; and Frédérique Végran, CRI INSERM UMR1231 “Lipids, Nutrition and Cancer,” Team “CAdIR,” Dijon, Burgundy, France. E-mail: frederique.vegran{at}inserm.fr
  1. ↵#F. Végran and R. Boidot contributed equally to this article.

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Cancer Immunology Research: 9 (3)
March 2021
Volume 9, Issue 3
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The Tumor Microenvironment Impairs Th1 IFNγ Secretion through Alternative Splicing Modifications of Irf1 Pre-mRNA
Antoine Bernard, Christophe Hibos, Corentin Richard, Etienne Viltard, Sandy Chevrier, Sophie Lemoine, Joséphine Melin, Etienne Humblin, Romain Mary, Théo Accogli, Fanny Chalmin, Mélanie Bruchard, Paul Peixoto, Eric Hervouet, Lionel Apetoh, François Ghiringhelli, Frédérique Végran and Romain Boidot
Cancer Immunol Res March 1 2021 (9) (3) 324-336; DOI: 10.1158/2326-6066.CIR-19-0679

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The Tumor Microenvironment Impairs Th1 IFNγ Secretion through Alternative Splicing Modifications of Irf1 Pre-mRNA
Antoine Bernard, Christophe Hibos, Corentin Richard, Etienne Viltard, Sandy Chevrier, Sophie Lemoine, Joséphine Melin, Etienne Humblin, Romain Mary, Théo Accogli, Fanny Chalmin, Mélanie Bruchard, Paul Peixoto, Eric Hervouet, Lionel Apetoh, François Ghiringhelli, Frédérique Végran and Romain Boidot
Cancer Immunol Res March 1 2021 (9) (3) 324-336; DOI: 10.1158/2326-6066.CIR-19-0679
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