Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers; Jacob E. Gillis; Tara Muijlwijk; Thao H. Nguyen; Emily F. Gaudiano; Isaac S. Harris; Martin W. LaFleur; Alison E. Ringel; Cong-Hui Yao; Kiran Kurmi; Vikram R. Juneja; Justin D. Trombley; Marcia C. Haigis; Arlene H. Sharpe

doi:10.1158/2326-6066.CIR-20-0384

Research Articles

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8⁺ T Cells

Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris, Martin W. LaFleur, Alison E. Ringel, Cong-Hui Yao, Kiran Kurmi, Vikram R. Juneja, Justin D. Trombley, Marcia C. Haigis and Arlene H. Sharpe

Jefte M. Drijvers

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Jacob E. Gillis

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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ORCID record for Jacob E. Gillis

Tara Muijlwijk

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Thao H. Nguyen

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Emily F. Gaudiano

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Isaac S. Harris

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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Martin W. LaFleur

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Alison E. Ringel

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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Cong-Hui Yao

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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Kiran Kurmi

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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Vikram R. Juneja

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Justin D. Trombley

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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Marcia C. Haigis

2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

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For correspondence: arlene_sharpe@hms.harvard.edu marcia_haigis@hms.harvard.edu

Arlene H. Sharpe

1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.

3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.

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For correspondence: arlene_sharpe@hms.harvard.edu marcia_haigis@hms.harvard.edu

DOI: 10.1158/2326-6066.CIR-20-0384 Published February 2021

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February 2021
Volume 9, Issue 2

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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8⁺ T Cells