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Cancer Immunology Research
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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris, Martin W. LaFleur, Alison E. Ringel, Cong-Hui Yao, Kiran Kurmi, Vikram R. Juneja, Justin D. Trombley, Marcia C. Haigis and Arlene H. Sharpe
Jefte M. Drijvers
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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Jacob E. Gillis
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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  • ORCID record for Jacob E. Gillis
Tara Muijlwijk
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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  • ORCID record for Tara Muijlwijk
Thao H. Nguyen
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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Emily F. Gaudiano
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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  • ORCID record for Emily F. Gaudiano
Isaac S. Harris
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
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  • ORCID record for Isaac S. Harris
Martin W. LaFleur
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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Alison E. Ringel
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
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  • ORCID record for Alison E. Ringel
Cong-Hui Yao
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
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Kiran Kurmi
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
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Vikram R. Juneja
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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Justin D. Trombley
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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Marcia C. Haigis
2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: arlene_sharpe@hms.harvard.edu marcia_haigis@hms.harvard.edu
Arlene H. Sharpe
1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
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  • For correspondence: arlene_sharpe@hms.harvard.edu marcia_haigis@hms.harvard.edu
DOI: 10.1158/2326-6066.CIR-20-0384 Published February 2021
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Article Information

Volume 9, Issue 2, pp. 184-199

DOI 
https://doi.org/10.1158/2326-6066.CIR-20-0384
PubMed 
33277233

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received May 6, 2020
  • Revision received August 19, 2020
  • Accepted November 24, 2020
  • Published first December 4, 2020.

Article Versions

  • Previous version (December 4, 2020 - 06:11).
  • Previous version (December 17, 2020 - 05:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Jefte M. Drijvers1,2,3,
  2. Jacob E. Gillis1,3,#,
  3. Tara Muijlwijk1,3,#,
  4. Thao H. Nguyen1,3,#,
  5. Emily F. Gaudiano1,3,
  6. Isaac S. Harris2,
  7. Martin W. LaFleur1,3,
  8. Alison E. Ringel2,
  9. Cong-Hui Yao2,
  10. Kiran Kurmi2,
  11. Vikram R. Juneja1,3,
  12. Justin D. Trombley1,3,
  13. Marcia C. Haigis2,*, and
  14. Arlene H. Sharpe1,3,*
  1. 1Department of Immunology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
  2. 2Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts.
  3. 3Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Arlene H. Sharpe, Department of Immunology, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 837, Boston, MA 02115. Phone: 617-432-6569; Fax: 617-432-6570; E-mail: arlene_sharpe{at}hms.harvard.edu; and Marcia C. Haigis, Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, LHRRB Room 301A, Boston, MA 02115. Phone: 617-432-6865; Fax: 617-432-6932; E-mail: marcia_haigis{at}hms.harvard.edu
  1. ↵#J.E. Gillis, T. Muijlwijk, and T.H. Nguyen contributed equally to this article.

  • Current address for J.M. Drijvers: Third Rock Ventures, Boston, Massachusetts; current address for J.E. Gillis, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; current address for T. Muijlwijk, Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Otolaryngology/Head and Neck Surgery, Cancer Center Amsterdam, Amsterdam, the Netherlands; current address for I.S. Harris, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York; current address for V.R. Juneja, BioNTech SE, Cambridge, Massachusetts; and current address for J.D. Trombley, Michigan State University, East Lansing, Michigan.

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Cancer Immunology Research: 9 (2)
February 2021
Volume 9, Issue 2
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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris, Martin W. LaFleur, Alison E. Ringel, Cong-Hui Yao, Kiran Kurmi, Vikram R. Juneja, Justin D. Trombley, Marcia C. Haigis and Arlene H. Sharpe
Cancer Immunol Res February 1 2021 (9) (2) 184-199; DOI: 10.1158/2326-6066.CIR-20-0384

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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, Thao H. Nguyen, Emily F. Gaudiano, Isaac S. Harris, Martin W. LaFleur, Alison E. Ringel, Cong-Hui Yao, Kiran Kurmi, Vikram R. Juneja, Justin D. Trombley, Marcia C. Haigis and Arlene H. Sharpe
Cancer Immunol Res February 1 2021 (9) (2) 184-199; DOI: 10.1158/2326-6066.CIR-20-0384
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