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Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Emily J. Lelliott, Stefano Mangiola, Kelly M. Ramsbottom, Magnus Zethoven, Lydia Lim, Peter K.H. Lau, Amanda J. Oliver, Luciano G. Martelotto, Laura Kirby, Claire Martin, Riyaben P. Patel, Alison Slater, Carleen Cullinane, Anthony T. Papenfuss, Nicole M. Haynes, Grant A. McArthur, Jane Oliaro and Karen E. Sheppard
Emily J. Lelliott
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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Stefano Mangiola
3The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
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Kelly M. Ramsbottom
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Magnus Zethoven
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Lydia Lim
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Peter K.H. Lau
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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Amanda J. Oliver
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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Luciano G. Martelotto
4Single Cell Innovation Laboratory, The University of Melbourne, Parkville, Victoria, Australia.
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Laura Kirby
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Claire Martin
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Riyaben P. Patel
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Alison Slater
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Carleen Cullinane
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Anthony T. Papenfuss
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
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Nicole M. Haynes
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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Grant A. McArthur
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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Jane Oliaro
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
5Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
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Karen E. Sheppard
1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
6Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.
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  • For correspondence: karen.sheppard@petermac.org
DOI: 10.1158/2326-6066.CIR-20-0401 Published February 2021
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Article Information

Volume 9, Issue 2, pp. 136-146

DOI 
https://doi.org/10.1158/2326-6066.CIR-20-0401
PubMed 
33303574

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received May 13, 2020
  • Revision received September 14, 2020
  • Accepted December 4, 2020
  • Published first December 10, 2020.

Article Versions

  • Previous version (December 10, 2020 - 05:53).
  • Previous version (January 7, 2021 - 05:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Emily J. Lelliott1,2,
  2. Stefano Mangiola3,
  3. Kelly M. Ramsbottom1,
  4. Magnus Zethoven1,
  5. Lydia Lim1,
  6. Peter K.H. Lau1,2,
  7. Amanda J. Oliver1,2,
  8. Luciano G. Martelotto4,
  9. Laura Kirby1,
  10. Claire Martin1,
  11. Riyaben P. Patel1,
  12. Alison Slater1,
  13. Carleen Cullinane1,
  14. Anthony T. Papenfuss1,
  15. Nicole M. Haynes1,2,
  16. Grant A. McArthur1,2,#,
  17. Jane Oliaro1,2,5,#, and
  18. Karen E. Sheppard1,2,6,#,*
  1. 1Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  2. 2Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
  3. 3The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
  4. 4Single Cell Innovation Laboratory, The University of Melbourne, Parkville, Victoria, Australia.
  5. 5Department of Immunology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
  6. 6Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.
  1. ↵*Corresponding Author:
    Karen E. Sheppard, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia. Phone: 613-8559-6681; Fax: 613-8559-5039; E-mail: karen.sheppard{at}petermac.org
  1. ↵#G.A. McArthur, J. Oliaro, and K.E. Sheppard contributed equally to this article.

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Cancer Immunology Research: 9 (2)
February 2021
Volume 9, Issue 2
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Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott, Stefano Mangiola, Kelly M. Ramsbottom, Magnus Zethoven, Lydia Lim, Peter K.H. Lau, Amanda J. Oliver, Luciano G. Martelotto, Laura Kirby, Claire Martin, Riyaben P. Patel, Alison Slater, Carleen Cullinane, Anthony T. Papenfuss, Nicole M. Haynes, Grant A. McArthur, Jane Oliaro and Karen E. Sheppard
Cancer Immunol Res February 1 2021 (9) (2) 136-146; DOI: 10.1158/2326-6066.CIR-20-0401

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Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott, Stefano Mangiola, Kelly M. Ramsbottom, Magnus Zethoven, Lydia Lim, Peter K.H. Lau, Amanda J. Oliver, Luciano G. Martelotto, Laura Kirby, Claire Martin, Riyaben P. Patel, Alison Slater, Carleen Cullinane, Anthony T. Papenfuss, Nicole M. Haynes, Grant A. McArthur, Jane Oliaro and Karen E. Sheppard
Cancer Immunol Res February 1 2021 (9) (2) 136-146; DOI: 10.1158/2326-6066.CIR-20-0401
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