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Abstract
Genetically identical cells in a tissue can respond differently to perturbations in their environment or “stress.” Such stresses can be physicochemical, mechanical, or infectious or may come from competition with other cells in the tissue. Here, I discuss how the varying responses to stress influence the decision of a cell to repair or die, and how one cell's response can have effects on surrounding cells. Such responses control the health and fitness of single cells and how they compete with other genetically identical cells.
See related article on p. 129
Footnotes
Cancer Immunol Res 2021;9:130–5
- Received May 19, 2020.
- Revision received September 14, 2020.
- Accepted November 18, 2020.
- ©2021 American Association for Cancer Research.
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Volume 9, Issue 2
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- Article
- Abstract
- Introduction: What Is “Health” in a Cell?
- Health versus Fitness at the Single-Cell Level
- The Challenges to Cellular Health
- Responses to Cell Stress: The Repair or Die Decision
- Responses to Cellular Stress: Abscopal Effects
- Conclusion: Cell Competition, Cell Cooperation, Cell Death, and Abscopal Responses to Stress
- Author's Disclosures
- Acknowledgments
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