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Volume 9, Issue 1, pp. 2-7
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- Published first January 4, 2021.
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©2021 American Association for Cancer Research.
Author Information
- Zhibin Zhang,
- Ying Zhang, and
- Judy Lieberman*
- Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
- ↵*Corresponding Author:
Judy Lieberman, Boston Children's Hospital and Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115. Phone: 617-713-8600; Fax: 617-713-8620; E-mail: judy.lieberman{at}childrens.harvard.edu
January 2021
Volume 9, Issue 1
Volume 9, Issue 1
Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?
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- Article
- Abstract
- Introduction to Gasdermins and Pyroptosis
- GSDME: A Tumor Suppressor?
- Inflammation in Cancer: A Double-Edged Sword
- GSDME Spontaneously Activates Antitumor Immunity
- Granzyme B Cleaves GSDME and Activates Pyroptosis
- Chimeric Antigen Receptor T–cell Activation of Pyroptosis Causes Cytokine Storm
- Granzyme A Activates Pyroptosis in GSDMB-Expressing Tumors
- Harnessing Tumor Cell Pyroptosis for Immunotherapy
- Contribution of Pyroptosis to Chemotherapy Toxicity
- Concluding Remarks
- Authors' Disclosures
- Acknowledgments
- Footnotes
- References
- Figures & Data
- Info & Metrics
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