Activation of CD8+ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors

Jessica L.F. Teh; Dan A. Erkes; Phil F. Cheng; Manoela Tiago; Nicole A. Wilski; Conroy O. Field; Inna Chervoneva; Mitch P. Levesque; Xiaowei Xu; Reinhard Dummer; Andrew E. Aplin

doi:10.1158/2326-6066.CIR-19-0743

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Activation of CD8⁺ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors

Jessica L.F. Teh, Dan A. Erkes, Phil F. Cheng, Manoela Tiago, Nicole A. Wilski, Conroy O. Field, Inna Chervoneva, Mitch P. Levesque, Xiaowei Xu, Reinhard Dummer and Andrew E. Aplin

Jessica L.F. Teh

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Dan A. Erkes

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Phil F. Cheng

2Department of Dermatology, University of Zurich Hospital, Zurich, Switzerland.

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Manoela Tiago

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Nicole A. Wilski

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Conroy O. Field

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Inna Chervoneva

3Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

4Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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Mitch P. Levesque

2Department of Dermatology, University of Zurich Hospital, Zurich, Switzerland.

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Xiaowei Xu

5Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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Reinhard Dummer

2Department of Dermatology, University of Zurich Hospital, Zurich, Switzerland.

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Andrew E. Aplin

1Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

4Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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For correspondence: Andrew.Aplin@Jefferson.edu

DOI: 10.1158/2326-6066.CIR-19-0743 Published September 2020

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September 2020
Volume 8, Issue 9

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Activation of CD8⁺ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors

Jessica L.F. Teh, Dan A. Erkes, Phil F. Cheng, Manoela Tiago, Nicole A. Wilski, Conroy O. Field, Inna Chervoneva, Mitch P. Levesque, Xiaowei Xu, Reinhard Dummer and Andrew E. Aplin

Cancer Immunol Res September 1 2020 (8) (9) 1114-1121; DOI: 10.1158/2326-6066.CIR-19-0743

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Activation of CD8⁺ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors

Jessica L.F. Teh, Dan A. Erkes, Phil F. Cheng, Manoela Tiago, Nicole A. Wilski, Conroy O. Field, Inna Chervoneva, Mitch P. Levesque, Xiaowei Xu, Reinhard Dummer and Andrew E. Aplin

Cancer Immunol Res September 1 2020 (8) (9) 1114-1121; DOI: 10.1158/2326-6066.CIR-19-0743

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