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Research Articles

Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype

Léa Paolini, Clément Adam, Céline Beauvillain, Laurence Preisser, Simon Blanchard, Pascale Pignon, Valérie Seegers, Louise-Marie Chevalier, Mario Campone, Romuald Wernert, Véronique Verrielle, Pedro Raro, Norbert Ifrah, Vincent Lavoué, Philippe Descamps, Alain Morel, Véronique Catros, Guillaume Tcherkez, Guy Lenaers, Cinzia Bocca, Judith Kouassi Nzoughet, Vincent Procaccio, Yves Delneste and Pascale Jeannin
Léa Paolini
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
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Clément Adam
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
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Céline Beauvillain
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
2Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
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Laurence Preisser
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
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Simon Blanchard
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
2Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
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Pascale Pignon
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
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Valérie Seegers
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
3Institut de Cancérologie de l'Ouest, Angers, France.
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Louise-Marie Chevalier
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
3Institut de Cancérologie de l'Ouest, Angers, France.
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Mario Campone
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
3Institut de Cancérologie de l'Ouest, Angers, France.
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  • ORCID record for Mario Campone
Romuald Wernert
3Institut de Cancérologie de l'Ouest, Angers, France.
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Véronique Verrielle
3Institut de Cancérologie de l'Ouest, Angers, France.
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Pedro Raro
3Institut de Cancérologie de l'Ouest, Angers, France.
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Norbert Ifrah
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
4Service des Maladies du Sang, CHU d'Angers, Angers, France.
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Vincent Lavoué
5Service de Gynécologie-obstétrique, CHU de Rennes, Rennes, France.
6UMR INSERM 1242, Université de Rennes, Rennes, France.
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Philippe Descamps
7Département de Gynécologie, CHU d'Angers, Angers, France.
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Alain Morel
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
3Institut de Cancérologie de l'Ouest, Angers, France.
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Véronique Catros
8CHU de Rennes, Rennes, France; UMR INSERM 991, Rennes, France; CRB Santé de Rennes, Rennes, France.
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Guillaume Tcherkez
9Research School of Biology, ANU Joint College of Sciences, Australian National University, Canberra, Australian Capital Territory, Australia.
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Guy Lenaers
10Université d'Angers, Inserm U1083, CNRS U6015, Institut MitoVasc, Angers, France.
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Cinzia Bocca
10Université d'Angers, Inserm U1083, CNRS U6015, Institut MitoVasc, Angers, France.
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Judith Kouassi Nzoughet
10Université d'Angers, Inserm U1083, CNRS U6015, Institut MitoVasc, Angers, France.
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Vincent Procaccio
10Université d'Angers, Inserm U1083, CNRS U6015, Institut MitoVasc, Angers, France.
11Département de Biochimie et Génétique, CHU d'Angers, Angers, France.
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Yves Delneste
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
2Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
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Pascale Jeannin
1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
2Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
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  • For correspondence: pascale.jeannin@univ-angers.fr
DOI: 10.1158/2326-6066.CIR-18-0749 Published March 2020
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Article Information

Volume 8, Issue 3, pp. 383-395

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0749
PubMed 
31924656

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received October 17, 2018
  • Revision received July 12, 2019
  • Accepted January 3, 2020
  • Published first January 10, 2020.

Article Versions

  • Previous version (January 10, 2020 - 05:36).
  • Previous version (February 6, 2020 - 05:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Léa Paolini1,#,
  2. Clément Adam1,#,
  3. Céline Beauvillain1,2,
  4. Laurence Preisser1,
  5. Simon Blanchard1,2,
  6. Pascale Pignon1,
  7. Valérie Seegers1,3,
  8. Louise-Marie Chevalier1,3,
  9. Mario Campone1,3,
  10. Romuald Wernert3,
  11. Véronique Verrielle3,
  12. Pedro Raro3,
  13. Norbert Ifrah1,4,
  14. Vincent Lavoué5,6,
  15. Philippe Descamps7,
  16. Alain Morel1,3,
  17. Véronique Catros8,
  18. Guillaume Tcherkez9,
  19. Guy Lenaers10,
  20. Cinzia Bocca10,
  21. Judith Kouassi Nzoughet10,
  22. Vincent Procaccio10,11,
  23. Yves Delneste1,2,#, and
  24. Pascale Jeannin1,2,#,*
  1. 1Université d'Angers, CHU d'Angers, Inserm U1232, CRCINA, Angers, France.
  2. 2Laboratoire d'Immunologie et Allergologie, CHU d'Angers, Angers, France.
  3. 3Institut de Cancérologie de l'Ouest, Angers, France.
  4. 4Service des Maladies du Sang, CHU d'Angers, Angers, France.
  5. 5Service de Gynécologie-obstétrique, CHU de Rennes, Rennes, France.
  6. 6UMR INSERM 1242, Université de Rennes, Rennes, France.
  7. 7Département de Gynécologie, CHU d'Angers, Angers, France.
  8. 8CHU de Rennes, Rennes, France; UMR INSERM 991, Rennes, France; CRB Santé de Rennes, Rennes, France.
  9. 9Research School of Biology, ANU Joint College of Sciences, Australian National University, Canberra, Australian Capital Territory, Australia.
  10. 10Université d'Angers, Inserm U1083, CNRS U6015, Institut MitoVasc, Angers, France.
  11. 11Département de Biochimie et Génétique, CHU d'Angers, Angers, France.
  1. ↵*Corresponding Author:
    Pascale Jeannin, CRCINA – Unité INSERM 1232, CHU d'Angers, 4 rue Larrey, 49933 Angers, France. Phone: 33-0-244-688-311; Fax: 33-0-244-688-594; E-mail: pascale.jeannin{at}univ-angers.fr
  1. ↵#L. Paolini and C. Adam contributed equally to this article.

  2. ↵#Y. Delneste and P. Jeannin jointly supervised this article.

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Cancer Immunology Research: 8 (3)
March 2020
Volume 8, Issue 3
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Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype
Léa Paolini, Clément Adam, Céline Beauvillain, Laurence Preisser, Simon Blanchard, Pascale Pignon, Valérie Seegers, Louise-Marie Chevalier, Mario Campone, Romuald Wernert, Véronique Verrielle, Pedro Raro, Norbert Ifrah, Vincent Lavoué, Philippe Descamps, Alain Morel, Véronique Catros, Guillaume Tcherkez, Guy Lenaers, Cinzia Bocca, Judith Kouassi Nzoughet, Vincent Procaccio, Yves Delneste and Pascale Jeannin
Cancer Immunol Res March 1 2020 (8) (3) 383-395; DOI: 10.1158/2326-6066.CIR-18-0749

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Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype
Léa Paolini, Clément Adam, Céline Beauvillain, Laurence Preisser, Simon Blanchard, Pascale Pignon, Valérie Seegers, Louise-Marie Chevalier, Mario Campone, Romuald Wernert, Véronique Verrielle, Pedro Raro, Norbert Ifrah, Vincent Lavoué, Philippe Descamps, Alain Morel, Véronique Catros, Guillaume Tcherkez, Guy Lenaers, Cinzia Bocca, Judith Kouassi Nzoughet, Vincent Procaccio, Yves Delneste and Pascale Jeannin
Cancer Immunol Res March 1 2020 (8) (3) 383-395; DOI: 10.1158/2326-6066.CIR-18-0749
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