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Cancer Immunology Research
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Research Articles

B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

Bhalchandra Mirlekar, Daniel Michaud, Samuel J. Lee, Nancy P. Kren, Cameron Harris, Kevin Greene, Emily C. Goldman, Gaorav P. Gupta, Ryan C. Fields, William G. Hawkins, David G. DeNardo, Naim U. Rashid, Jen Jen Yeh, Autumn J. McRee, Benjamin G. Vincent, Dario A.A. Vignali and Yuliya Pylayeva-Gupta
Bhalchandra Mirlekar
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Daniel Michaud
2Department of Cell Biology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Samuel J. Lee
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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  • ORCID record for Samuel J. Lee
Nancy P. Kren
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Cameron Harris
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Kevin Greene
3Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Emily C. Goldman
4Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Gaorav P. Gupta
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
4Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Ryan C. Fields
5Department of Surgery, Barnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
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William G. Hawkins
5Department of Surgery, Barnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
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David G. DeNardo
6Department of Medicine, Barnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
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Naim U. Rashid
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
7Department of Biostatistics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Jen Jen Yeh
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
8Department of Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Autumn J. McRee
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
9Department of Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Benjamin G. Vincent
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
9Department of Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
10Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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Dario A.A. Vignali
11Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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  • ORCID record for Dario A.A. Vignali
Yuliya Pylayeva-Gupta
1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
12Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
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  • For correspondence: yuliyap1@email.unc.edu
DOI: 10.1158/2326-6066.CIR-19-0349 Published March 2020
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Article Information

Volume 8, Issue 3, pp. 292-308

DOI 
https://doi.org/10.1158/2326-6066.CIR-19-0349
PubMed 
32024640

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received May 15, 2019
  • Revision received September 13, 2019
  • Accepted December 9, 2019
  • Published first February 5, 2020.

Article Versions

  • Previous version (February 5, 2020 - 05:55).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Bhalchandra Mirlekar1,
  2. Daniel Michaud2,
  3. Samuel J. Lee1,
  4. Nancy P. Kren1,
  5. Cameron Harris1,
  6. Kevin Greene3,
  7. Emily C. Goldman4,
  8. Gaorav P. Gupta1,4,
  9. Ryan C. Fields5,
  10. William G. Hawkins5,
  11. David G. DeNardo6,
  12. Naim U. Rashid1,7,
  13. Jen Jen Yeh1,8,
  14. Autumn J. McRee1,9,
  15. Benjamin G. Vincent1,9,10,
  16. Dario A.A. Vignali11, and
  17. Yuliya Pylayeva-Gupta1,12,*
  1. 1Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  2. 2Department of Cell Biology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  3. 3Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  4. 4Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  5. 5Department of Surgery, Barnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
  6. 6Department of Medicine, Barnes-Jewish Hospital and the Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, Missouri.
  7. 7Department of Biostatistics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  8. 8Department of Surgery, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  9. 9Department of Medicine, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  10. 10Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  11. 11Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  12. 12Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
  1. ↵*Corresponding Author:
    Yuliya Pylayeva-Gupta, The University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599. Phone: 919-962-8296; Fax: 919-966-8212; E-mail: yuliyap1{at}email.unc.edu
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Cancer Immunology Research: 8 (3)
March 2020
Volume 8, Issue 3
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B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
Bhalchandra Mirlekar, Daniel Michaud, Samuel J. Lee, Nancy P. Kren, Cameron Harris, Kevin Greene, Emily C. Goldman, Gaorav P. Gupta, Ryan C. Fields, William G. Hawkins, David G. DeNardo, Naim U. Rashid, Jen Jen Yeh, Autumn J. McRee, Benjamin G. Vincent, Dario A.A. Vignali and Yuliya Pylayeva-Gupta
Cancer Immunol Res March 1 2020 (8) (3) 292-308; DOI: 10.1158/2326-6066.CIR-19-0349

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B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer
Bhalchandra Mirlekar, Daniel Michaud, Samuel J. Lee, Nancy P. Kren, Cameron Harris, Kevin Greene, Emily C. Goldman, Gaorav P. Gupta, Ryan C. Fields, William G. Hawkins, David G. DeNardo, Naim U. Rashid, Jen Jen Yeh, Autumn J. McRee, Benjamin G. Vincent, Dario A.A. Vignali and Yuliya Pylayeva-Gupta
Cancer Immunol Res March 1 2020 (8) (3) 292-308; DOI: 10.1158/2326-6066.CIR-19-0349
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