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Cancer Immunology Research
Cancer Immunology Research
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Table of Contents

What We're Reading

  • What We're Reading
    A Sampling of Highlights from the Literature
    Cancer Immunol Res February 1 2020 8 (2) 159-159;

In the Spotlight

  • In the Spotlight
    Macrophages Instruct Aberrant Glycosylation in Colon Cancer by Chemokine and Cytokine Signals
    Vincenzo Bronte
    Cancer Immunol Res February 1 2020 8 (2) 160-160; DOI:10.1158/2326-6066.CIR-19-1005

Cancer Immunology at the Crossroads

  • Cancer Immunology at the Crossroads | AuthorChoice
    Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies
    Dana L. Casey and Nai-Kong V. Cheung
    Cancer Immunol Res February 1 2020 8 (2) 161-166; DOI:10.1158/2326-6066.CIR-19-0692

Research Articles

  • Research Articles
    Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer
    Michael Kvorjak, Yasmine Ahmed, Michelle L. Miller, Raahul Sriram, Claudia Coronnello, Jana G. Hashash, Douglas J. Hartman, Cheryl A. Telmer, Natasa Miskov-Zivanov, Olivera J. Finn and Sandra Cascio
    Cancer Immunol Res February 1 2020 8 (2) 167-178; DOI:10.1158/2326-6066.CIR-19-0514

    Posttranslational modifications of oncoproteins can promote tumor development, yet it is unclear what induces these alterations. In UC and CACC, M2-like macrophages produce CCL17 and IL13, which increases ST6GALNAC1 glycosyltransferase, leading to glycosylated MUC1 in colon cancer cells.

  • Research Articles
    Targeting CMTM6 Suppresses Stem Cell–Like Properties and Enhances Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
    Lei Chen, Qi-Chao Yang, Yi-Cun Li, Lei-Lei Yang, Jian-Feng Liu, Hao Li, Yao Xiao, Lin-Lin Bu, Wen-Feng Zhang and Zhi-Jun Sun
    Cancer Immunol Res February 1 2020 8 (2) 179-191; DOI:10.1158/2326-6066.CIR-19-0394

    Elevated CMTM6 in patients with HNSCC predicted poor prognosis. Without CMTM6, cancer stem cell features and the proportion of exhausted T cells decrease, concomitantly improving antitumor immunity. Thus, CMTM6 may have potential as a therapeutic target.

  • Research Articles
    Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors
    Karin Schreiber, Theodore G. Karrison, Steven P. Wolf, Kazuma Kiyotani, Madeline Steiner, Eric R. Littmann, Eric G. Pamer, Thomas Kammertoens, Hans Schreiber and Matthias Leisegang
    Cancer Immunol Res February 1 2020 8 (2) 192-202; DOI:10.1158/2326-6066.CIR-19-0567

    Sibling mice from the same parental breeding pair and with similar microbiomes exhibit differing TCR repertoires. Thus, rejection of inoculated or chemically induced tumors differs, highlighting the important role of T-cell diversity in response to cancer.

  • Research Articles | AuthorChoice
    Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses
    Megat Abd Hamid, Huw Colin-York, Nasullah Khalid-Alham, Molly Browne, Lucia Cerundolo, Ji-Li Chen, Xuan Yao, Samara Rosendo-Machado, Craig Waugh, David Maldonado-Perez, Emma Bowes, Clare Verrill, Vincenzo Cerundolo, Christopher P. Conlon, Marco Fritzsche, Yanchun Peng and Tao Dong
    Cancer Immunol Res February 1 2020 8 (2) 203-216; DOI:10.1158/2326-6066.CIR-19-0554

    Antigen-specific CD103+CD8+ T cells can self-regulate their CD103 expression by producing active TGFβ1 and have better TCR antigen sensitivity and enhanced effector functions versus CD103− populations. However, this population undergoes increased death with prolonged exposure to tumor cells.

  • Research Articles
    Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention
    Coral Omene, Lin Ma, Jade Moore, Haoxu Ouyang, Irineu Illa-Bochaca, William Chou, Manan S. Patel, Christopher Sebastiano, Sandra Demaria, Jian-Hua Mao, Kubra Karagoz, Michael L. Gatza and Mary Helen Barcellos-Hoff
    Cancer Immunol Res February 1 2020 8 (2) 217-229; DOI:10.1158/2326-6066.CIR-19-0253

    Systemic effects of whole-body irradiation can fuel carcinogenesis by repressing antitumor immunity in a mouse model of breast cancer. Aggressive tumors lacking lymphocytic infiltrate can be prevented by dietary intervention with a nontoxic, immunomodulatory agent known as CAPE.

  • Research Articles | AuthorChoice
    CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity
    Suresh de Silva, George Fromm, Casey W. Shuptrine, Kellsey Johannes, Arpita Patel, Kyung Jin Yoo, Kaiwen Huang and Taylor H. Schreiber
    Cancer Immunol Res February 1 2020 8 (2) 230-245; DOI:10.1158/2326-6066.CIR-19-0493

    Blocking CD47/SIRPα interactions induces antitumor efficacy. A dual fusion protein incorporating SIRPα and CD40L potentiates tumor cell phagocytosis and type I interferon responses, improving control of established tumors and sensitivity to immune checkpoint blockade.

  • Research Articles | AuthorChoice
    Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses
    Samantha K. Greaney, Alain P. Algazi, Katy K. Tsai, Kathryn T. Takamura, Lawrence Chen, Christopher G. Twitty, Li Zhang, Alan Paciorek, Robert H. Pierce, Mai H. Le, Adil I. Daud and Lawrence Fong
    Cancer Immunol Res February 1 2020 8 (2) 246-254; DOI:10.1158/2326-6066.CIR-19-0359

    Systemic IL12 use is limited due to toxicity, yet intratumoral administration of an IL12 plasmid via electroporation is safe and efficacious, even at distant sites. In melanoma patients, this treatment induces local and systemic antigen-specific T-cell responses.

  • Research Articles
    MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
    Virginie Vignard, Maureen Labbé, Nadège Marec, Gwennan André-Grégoire, Nicolas Jouand, Jean-François Fonteneau, Nathalie Labarrière and Delphine Fradin
    Cancer Immunol Res February 1 2020 8 (2) 255-267; DOI:10.1158/2326-6066.CIR-19-0522

    CD8+ T cells not only interact with tumor exosomes but also internalize them, providing a route by which miRNAs encapsulated in exosomes contribute to immune escape mechanisms.

  • Research Articles
    Immunoregulation and Clinical Implications of ANGPT2/TIE2+ M-MDSC Signature in Non–Small Cell Lung Cancer
    Elodie Lauret Marie Joseph, Caroline Laheurte, Marine Jary, Laura Boullerot, Kamal Asgarov, Eléonore Gravelin, Adeline Bouard, Laurie Rangan, Magalie Dosset, Christophe Borg and Olivier Adotévi
    Cancer Immunol Res February 1 2020 8 (2) 268-279; DOI:10.1158/2326-6066.CIR-19-0326

    Tumor immune evasion in NSCLC is promoted by overexpression of angiopoietin-2 (ANGPT2) and overaccumulation of M-MDSCs that express the ANGPT2-receptor, TIE2. The ANGPT2/TIE2+ M-MDSC axis could be useful for stratification of NSCLC patients and for therapy decisions.

Correction

  • Correction | Free Article
    Correction: All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages
    Cancer Immunol Res February 1 2020 8 (2) 280-280; DOI:10.1158/2326-6066.CIR-19-0971

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Cancer Immunology Research: 8 (2)
February 2020
Volume 8, Issue 2
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Cancer Immunology Research
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