Table of Contents

Research Articles

• Research Articles

  Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer

  Michael Kvorjak, Yasmine Ahmed, Michelle L. Miller, Raahul Sriram, Claudia Coronnello, Jana G. Hashash, Douglas J. Hartman, Cheryl A. Telmer, Natasa Miskov-Zivanov, Olivera J. Finn and Sandra Cascio

  Cancer Immunol Res February 1 2020 8 (2) 167-178; DOI:10.1158/2326-6066.CIR-19-0514

  
  

  Posttranslational modifications of oncoproteins can promote tumor development, yet it is unclear what induces these alterations. In UC and CACC, M2-like macrophages produce CCL17 and IL13, which increases ST6GALNAC1 glycosyltransferase, leading to glycosylated MUC1 in colon cancer cells.
• Research Articles

  Targeting CMTM6 Suppresses Stem Cell–Like Properties and Enhances Antitumor Immunity in Head and Neck Squamous Cell Carcinoma

  Lei Chen, Qi-Chao Yang, Yi-Cun Li, Lei-Lei Yang, Jian-Feng Liu, Hao Li, Yao Xiao, Lin-Lin Bu, Wen-Feng Zhang and Zhi-Jun Sun

  Cancer Immunol Res February 1 2020 8 (2) 179-191; DOI:10.1158/2326-6066.CIR-19-0394

  
  

  Elevated CMTM6 in patients with HNSCC predicted poor prognosis. Without CMTM6, cancer stem cell features and the proportion of exhausted T cells decrease, concomitantly improving antitumor immunity. Thus, CMTM6 may have potential as a therapeutic target.
• Research Articles

  Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors

  Karin Schreiber, Theodore G. Karrison, Steven P. Wolf, Kazuma Kiyotani, Madeline Steiner, Eric R. Littmann, Eric G. Pamer, Thomas Kammertoens, Hans Schreiber and Matthias Leisegang

  Cancer Immunol Res February 1 2020 8 (2) 192-202; DOI:10.1158/2326-6066.CIR-19-0567

  
  

  Sibling mice from the same parental breeding pair and with similar microbiomes exhibit differing TCR repertoires. Thus, rejection of inoculated or chemically induced tumors differs, highlighting the important role of T-cell diversity in response to cancer.
• Research Articles | AuthorChoice

  Self-Maintaining CD103⁺ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses

  Megat Abd Hamid, Huw Colin-York, Nasullah Khalid-Alham, Molly Browne, Lucia Cerundolo, Ji-Li Chen, Xuan Yao, Samara Rosendo-Machado, Craig Waugh, David Maldonado-Perez, Emma Bowes, Clare Verrill, Vincenzo Cerundolo, Christopher P. Conlon, Marco Fritzsche, Yanchun Peng and Tao Dong

  Cancer Immunol Res February 1 2020 8 (2) 203-216; DOI:10.1158/2326-6066.CIR-19-0554

  
  

  Antigen-specific CD103⁺CD8⁺ T cells can self-regulate their CD103 expression by producing active TGFβ1 and have better TCR antigen sensitivity and enhanced effector functions versus CD103⁻ populations. However, this population undergoes increased death with prolonged exposure to tumor cells.
• Research Articles

  Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention

  Coral Omene, Lin Ma, Jade Moore, Haoxu Ouyang, Irineu Illa-Bochaca, William Chou, Manan S. Patel, Christopher Sebastiano, Sandra Demaria, Jian-Hua Mao, Kubra Karagoz, Michael L. Gatza and Mary Helen Barcellos-Hoff

  Cancer Immunol Res February 1 2020 8 (2) 217-229; DOI:10.1158/2326-6066.CIR-19-0253

  
  

  Systemic effects of whole-body irradiation can fuel carcinogenesis by repressing antitumor immunity in a mouse model of breast cancer. Aggressive tumors lacking lymphocytic infiltrate can be prevented by dietary intervention with a nontoxic, immunomodulatory agent known as CAPE.
• Research Articles | AuthorChoice

  CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity

  Suresh de Silva, George Fromm, Casey W. Shuptrine, Kellsey Johannes, Arpita Patel, Kyung Jin Yoo, Kaiwen Huang and Taylor H. Schreiber

  Cancer Immunol Res February 1 2020 8 (2) 230-245; DOI:10.1158/2326-6066.CIR-19-0493

  
  

  Blocking CD47/SIRPα interactions induces antitumor efficacy. A dual fusion protein incorporating SIRPα and CD40L potentiates tumor cell phagocytosis and type I interferon responses, improving control of established tumors and sensitivity to immune checkpoint blockade.
• Research Articles | AuthorChoice

  Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses

  Samantha K. Greaney, Alain P. Algazi, Katy K. Tsai, Kathryn T. Takamura, Lawrence Chen, Christopher G. Twitty, Li Zhang, Alan Paciorek, Robert H. Pierce, Mai H. Le, Adil I. Daud and Lawrence Fong

  Cancer Immunol Res February 1 2020 8 (2) 246-254; DOI:10.1158/2326-6066.CIR-19-0359

  
  

  Systemic IL12 use is limited due to toxicity, yet intratumoral administration of an IL12 plasmid via electroporation is safe and efficacious, even at distant sites. In melanoma patients, this treatment induces local and systemic antigen-specific T-cell responses.
• Research Articles

  MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma

  Virginie Vignard, Maureen Labbé, Nadège Marec, Gwennan André-Grégoire, Nicolas Jouand, Jean-François Fonteneau, Nathalie Labarrière and Delphine Fradin

  Cancer Immunol Res February 1 2020 8 (2) 255-267; DOI:10.1158/2326-6066.CIR-19-0522

  
  

  CD8⁺ T cells not only interact with tumor exosomes but also internalize them, providing a route by which miRNAs encapsulated in exosomes contribute to immune escape mechanisms.
• Research Articles

  Immunoregulation and Clinical Implications of ANGPT2/TIE2⁺ M-MDSC Signature in Non–Small Cell Lung Cancer

  Elodie Lauret Marie Joseph, Caroline Laheurte, Marine Jary, Laura Boullerot, Kamal Asgarov, Eléonore Gravelin, Adeline Bouard, Laurie Rangan, Magalie Dosset, Christophe Borg and Olivier Adotévi

  Cancer Immunol Res February 1 2020 8 (2) 268-279; DOI:10.1158/2326-6066.CIR-19-0326

  
  

  Tumor immune evasion in NSCLC is promoted by overexpression of angiopoietin-2 (ANGPT2) and overaccumulation of M-MDSCs that express the ANGPT2-receptor, TIE2. The ANGPT2/TIE2⁺ M-MDSC axis could be useful for stratification of NSCLC patients and for therapy decisions.