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An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Richard C.A. Sainson, Anil K. Thotakura, Miha Kosmac, Gwenoline Borhis, Nahida Parveen, Rachael Kimber, Joana Carvalho, Simon J. Henderson, Kerstin L. Pryke, Tracey Okell, Siobhan O'Leary, Stuart Ball, Cassie Van Krinks, Lauriane Gamand, Emma Taggart, Eleanor J. Pring, Hanif Ali, Hannah Craig, Vivian W.Y. Wong, Qi Liang, Robert J. Rowlands, Morgane Lecointre, Jamie Campbell, Ian Kirby, David Melvin, Volker Germaschewski, Elisabeth Oelmann, Sonia Quaratino and Matthew McCourt
Richard C.A. Sainson
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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  • For correspondence: richard.sainson@kymab.com
Anil K. Thotakura
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Miha Kosmac
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Gwenoline Borhis
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Nahida Parveen
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Rachael Kimber
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Joana Carvalho
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Simon J. Henderson
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Kerstin L. Pryke
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Tracey Okell
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Siobhan O'Leary
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Stuart Ball
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Cassie Van Krinks
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Lauriane Gamand
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Emma Taggart
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Eleanor J. Pring
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Hanif Ali
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Hannah Craig
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Vivian W.Y. Wong
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Qi Liang
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Robert J. Rowlands
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Morgane Lecointre
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Jamie Campbell
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Ian Kirby
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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David Melvin
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Volker Germaschewski
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Elisabeth Oelmann
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Sonia Quaratino
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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Matthew McCourt
Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
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DOI: 10.1158/2326-6066.CIR-20-0034 Published December 2020
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Article Information

Volume 8, Issue 12, pp. 1568-1582

DOI 
https://doi.org/10.1158/2326-6066.CIR-20-0034
PubMed 
32999002

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received January 14, 2020
  • Revision received June 1, 2020
  • Accepted September 18, 2020
  • Published first September 30, 2020.

Article Versions

  • Previous version (September 30, 2020 - 05:46).
  • Previous version (November 3, 2020 - 05:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Richard C.A. Sainson#,*,
  2. Anil K. Thotakura#,
  3. Miha Kosmac,
  4. Gwenoline Borhis,
  5. Nahida Parveen,
  6. Rachael Kimber,
  7. Joana Carvalho,
  8. Simon J. Henderson,
  9. Kerstin L. Pryke,
  10. Tracey Okell,
  11. Siobhan O'Leary,
  12. Stuart Ball,
  13. Cassie Van Krinks,
  14. Lauriane Gamand,
  15. Emma Taggart,
  16. Eleanor J. Pring,
  17. Hanif Ali,
  18. Hannah Craig,
  19. Vivian W.Y. Wong,
  20. Qi Liang,
  21. Robert J. Rowlands,
  22. Morgane Lecointre,
  23. Jamie Campbell,
  24. Ian Kirby,
  25. David Melvin,
  26. Volker Germaschewski,
  27. Elisabeth Oelmann,
  28. Sonia Quaratino, and
  29. Matthew McCourt
  1. Kymab Ltd, Babraham Research Campus, Cambridge, United Kingdom.
  1. ↵*Corresponding Author:
    Richard C.A. Sainson, Kymab Ltd, Babraham Research Institute, Bennet Building, Cambridge, Cambridgeshire CB22 3AT, UK. Phone: 44 (0)1223 833301; E-mail: richard.sainson{at}kymab.com
  1. ↵#R.C.A. Sainson and A.K. Thotakura contributed equally to this article.

  • Current address for J. Carvalho, SNIPR BIOME, Copenhagen, Denmark; current address for J. Campbell, Abcam plc, Cambridge, United Kingdom; and current address for I. Kirby, ADC Therapeutics, London, United Kingdom.

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Cancer Immunology Research: 8 (12)
December 2020
Volume 8, Issue 12
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An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression
Richard C.A. Sainson, Anil K. Thotakura, Miha Kosmac, Gwenoline Borhis, Nahida Parveen, Rachael Kimber, Joana Carvalho, Simon J. Henderson, Kerstin L. Pryke, Tracey Okell, Siobhan O'Leary, Stuart Ball, Cassie Van Krinks, Lauriane Gamand, Emma Taggart, Eleanor J. Pring, Hanif Ali, Hannah Craig, Vivian W.Y. Wong, Qi Liang, Robert J. Rowlands, Morgane Lecointre, Jamie Campbell, Ian Kirby, David Melvin, Volker Germaschewski, Elisabeth Oelmann, Sonia Quaratino and Matthew McCourt
Cancer Immunol Res December 1 2020 (8) (12) 1568-1582; DOI: 10.1158/2326-6066.CIR-20-0034

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An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression
Richard C.A. Sainson, Anil K. Thotakura, Miha Kosmac, Gwenoline Borhis, Nahida Parveen, Rachael Kimber, Joana Carvalho, Simon J. Henderson, Kerstin L. Pryke, Tracey Okell, Siobhan O'Leary, Stuart Ball, Cassie Van Krinks, Lauriane Gamand, Emma Taggart, Eleanor J. Pring, Hanif Ali, Hannah Craig, Vivian W.Y. Wong, Qi Liang, Robert J. Rowlands, Morgane Lecointre, Jamie Campbell, Ian Kirby, David Melvin, Volker Germaschewski, Elisabeth Oelmann, Sonia Quaratino and Matthew McCourt
Cancer Immunol Res December 1 2020 (8) (12) 1568-1582; DOI: 10.1158/2326-6066.CIR-20-0034
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