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Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA

Pengfei Wu, Bo Geng, Qun Chen, Enyang Zhao, Jiang Liu, Chen Sun, Caijun Zha, Yong Shao, Bosen You, Wenfu Zhang, Lulu Li, Xiangqi Meng, Jinquan Cai and Xuedong Li
Pengfei Wu
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
2Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China.
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Bo Geng
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Qun Chen
3Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
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Enyang Zhao
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Jiang Liu
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Chen Sun
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Caijun Zha
4Department of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Yong Shao
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Bosen You
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Wenfu Zhang
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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Lulu Li
2Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China.
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Xiangqi Meng
2Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China.
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Jinquan Cai
2Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China.
5Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum, Karolinska Institutet, Stockholm, Sweden.
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  • For correspondence: jinquan.cai@ki.se xdli1010@163.com
Xuedong Li
1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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  • For correspondence: jinquan.cai@ki.se xdli1010@163.com
DOI: 10.1158/2326-6066.CIR-20-0113 Published December 2020
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ARTICLE USAGE: September 2020 to March 2021

AbstractFull-text HTMLPDF
Total120310121050

Cited By

Article Information

Volume 8, Issue 12, pp. 1470-1484

DOI 
https://doi.org/10.1158/2326-6066.CIR-20-0113
PubMed 
32999004

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received February 4, 2020
  • Revision received June 4, 2020
  • Accepted September 24, 2020
  • Published first September 30, 2020.

Article Versions

  • Previous version (September 30, 2020 - 05:46).
  • Previous version (October 29, 2020 - 05:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Pengfei Wu1,2,#,
  2. Bo Geng1,#,
  3. Qun Chen3,#,
  4. Enyang Zhao1,
  5. Jiang Liu1,
  6. Chen Sun1,
  7. Caijun Zha4,
  8. Yong Shao1,
  9. Bosen You1,
  10. Wenfu Zhang1,
  11. Lulu Li2,
  12. Xiangqi Meng2,
  13. Jinquan Cai2,5,*, and
  14. Xuedong Li1,*
  1. 1Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  2. 2Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, China.
  3. 3Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  4. 4Department of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  5. 5Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum, Karolinska Institutet, Stockholm, Sweden.
  1. ↵*Corresponding Authors:
    Jinquan Cai, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 171 65 Stockholm, Sweden. Phone: 8615-1245-72707; E-mail: jinquan.cai{at}ki.se; and Xuedong Li, Department of Urology, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin, 150086 Heilongjiang, China. Phone: 86 13-6048-03553; E-mail: xdli1010{at}163.com
  1. ↵#P. Wu, B. Geng, and Q. Chen are co-first authors of this article.

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Cancer Immunology Research: 8 (12)
December 2020
Volume 8, Issue 12
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Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA
Pengfei Wu, Bo Geng, Qun Chen, Enyang Zhao, Jiang Liu, Chen Sun, Caijun Zha, Yong Shao, Bosen You, Wenfu Zhang, Lulu Li, Xiangqi Meng, Jinquan Cai and Xuedong Li
Cancer Immunol Res December 1 2020 (8) (12) 1470-1484; DOI: 10.1158/2326-6066.CIR-20-0113

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Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA
Pengfei Wu, Bo Geng, Qun Chen, Enyang Zhao, Jiang Liu, Chen Sun, Caijun Zha, Yong Shao, Bosen You, Wenfu Zhang, Lulu Li, Xiangqi Meng, Jinquan Cai and Xuedong Li
Cancer Immunol Res December 1 2020 (8) (12) 1470-1484; DOI: 10.1158/2326-6066.CIR-20-0113
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