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TGFβ: Protecting PD-1 from mRNA Decay

Stephanie K. Dougan
Stephanie K. Dougan
Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • For correspondence: stephanie_dougan@dfci.harvard.edu
DOI: 10.1158/2326-6066.CIR-20-0881 Published December 2020
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Abstract

Coordinated regulation of genes is key to determining cell fate. Although this is best understood for master regulator transcription factors, posttranscriptional regulation of mRNA stability and nuclear export can be equally effective at altering gene expression. Indeed, the heterogeneity of RNA-binding proteins and miRNAs suggests a deep complexity to posttranscriptional regulatory processes. In this issue, Wu and colleagues report a new mechanism for TGFβ-mediated immune suppression via regulation of mRNA-binding proteins in CD8+ T cells.

See article by Wu et al., p. 1470

Footnotes

  • Cancer Immunol Res 2020;8:1464

  • ©2020 American Association for Cancer Research.
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Cancer Immunology Research: 8 (12)
December 2020
Volume 8, Issue 12
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TGFβ: Protecting PD-1 from mRNA Decay
Stephanie K. Dougan
Cancer Immunol Res December 1 2020 (8) (12) 1464; DOI: 10.1158/2326-6066.CIR-20-0881

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TGFβ: Protecting PD-1 from mRNA Decay
Stephanie K. Dougan
Cancer Immunol Res December 1 2020 (8) (12) 1464; DOI: 10.1158/2326-6066.CIR-20-0881
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Cancer Immunology Research
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