Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Mariana C. Silva; Ângela Fernandes; Maria Oliveira; Carlos Resende; Alexandra Correia; Julio C. de-Freitas-Junior; Aonghus Lavelle; Jéssica Andrade-da-Costa; Magdalena Leander; Helena Xavier-Ferreira; José Bessa; Carina Pereira; Rui M. Henrique; Fátima Carneiro; Mário Dinis-Ribeiro; Ricardo Marcos-Pinto; Margarida Lima; Bernd Lepenies; Harry Sokol; José C. Machado; Manuel Vilanova; Salomé S. Pinho

doi:10.1158/2326-6066.CIR-20-0264

Research Articles

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Mariana C. Silva, Ângela Fernandes, Maria Oliveira, Carlos Resende, Alexandra Correia, Julio C. de-Freitas-Junior, Aonghus Lavelle, Jéssica Andrade-da-Costa, Magdalena Leander, Helena Xavier-Ferreira, José Bessa, Carina Pereira, Rui M. Henrique, Fátima Carneiro, Mário Dinis-Ribeiro, Ricardo Marcos-Pinto, Margarida Lima, Bernd Lepenies, Harry Sokol, José C. Machado, Manuel Vilanova and Salomé S. Pinho

Mariana C. Silva

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Ângela Fernandes

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

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Maria Oliveira

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

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Carlos Resende

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

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Alexandra Correia

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Julio C. de-Freitas-Junior

3Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.

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Aonghus Lavelle

4Sorbonne Université, INSERM, Saint-Antoine Research Center (CRSA), Paris, France.

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Jéssica Andrade-da-Costa

3Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.

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Magdalena Leander

5Department of Hematology, Hospital Center of Porto, Porto, Portugal.

6Multidisciplinary Unit for Biomedical Research, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Helena Xavier-Ferreira

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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José Bessa

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

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Carina Pereira

7CINTESIS – Centre for Health Technology and Services Research, University of Porto, Porto, Portugal.

8Molecular Oncology and Viral Pathology Group, IPO Porto Research Group (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

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ORCID record for Carina Pereira

Rui M. Henrique

9Department of Pathology and Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

10Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Fátima Carneiro

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

11Department of Pathology, Hospital Center of São João, Porto, Portugal.

12Faculty of Medicine, University of Porto, Porto, Portugal.

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Mário Dinis-Ribeiro

7CINTESIS – Centre for Health Technology and Services Research, University of Porto, Porto, Portugal.

13Department of Gastroenterology, Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.

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Ricardo Marcos-Pinto

2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

14Department of Gastroenterology, Hospital Center of Porto, Porto, Portugal.

15Medical Faculty, Centre for Research in Health Technologies and Information Systems, Porto, Portugal.

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Margarida Lima

5Department of Hematology, Hospital Center of Porto, Porto, Portugal.

6Multidisciplinary Unit for Biomedical Research, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Bernd Lepenies

16Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.

17Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.

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Harry Sokol

4Sorbonne Université, INSERM, Saint-Antoine Research Center (CRSA), Paris, France.

18INRA, UMR1319 Micalis, AgroParisTech, Jouy-en-Josas, France.

19Department of Gastroenterology, Saint Antoine Hospital, Assistance Publique - Hopitaux de Paris, Sorbonne Universités, Paris, France.

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José C. Machado

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

12Faculty of Medicine, University of Porto, Porto, Portugal.

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Manuel Vilanova

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

2Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.

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Salomé S. Pinho

1Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.

12Faculty of Medicine, University of Porto, Porto, Portugal.

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For correspondence: salomep@ipatimup.pt

DOI: 10.1158/2326-6066.CIR-20-0264 Published November 2020

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November 2020
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Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Cancer Immunol Res November 1 2020 (8) (11) 1407-1425; DOI: 10.1158/2326-6066.CIR-20-0264

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Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Cancer Immunol Res November 1 2020 (8) (11) 1407-1425; DOI: 10.1158/2326-6066.CIR-20-0264

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