High Numbers of Circulating CD57+ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2+ Primary Breast Cancer

Aura Muntasell; Sònia Servitja; Mariona Cabo; Begoña Bermejo; Sandra Pérez-Buira; Federico Rojo; Marcel Costa-García; Oriol Arpí; Manuela Moraru; Laia Serrano; Ignasi Tusquets; María Teresa Martínez; Gemma Heredia; Andrea Vera; María Martínez-García; Laura Soria; Laura Comerma; Sara Santana-Hernández; Pilar Eroles; Ana Rovira; Carlos Vilches; Ana Lluch; Joan Albanell; Miguel López-Botet

doi:10.1158/2326-6066.CIR-18-0896

Research Articles

High Numbers of Circulating CD57⁺ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2⁺ Primary Breast Cancer

Aura Muntasell, Sònia Servitja, Mariona Cabo, Begoña Bermejo, Sandra Pérez-Buira, Federico Rojo, Marcel Costa-García, Oriol Arpí, Manuela Moraru, Laia Serrano, Ignasi Tusquets, María Teresa Martínez, Gemma Heredia, Andrea Vera, María Martínez-García, Laura Soria, Laura Comerma, Sara Santana-Hernández, Pilar Eroles, Ana Rovira, Carlos Vilches, Ana Lluch, Joan Albanell and Miguel López-Botet

Aura Muntasell

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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ORCID record for Aura Muntasell
For correspondence: amuntasell@imim.es jalbanell@hospitaldelmar.cat

Sònia Servitja

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Department of Medical Oncology, Hospital del Mar-CIBERONC, Barcelona, Spain.

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Mariona Cabo

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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Begoña Bermejo

Department of Oncology, Hospital Clinico de Valencia-CIBERONC, Valencia, Spain.

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Sandra Pérez-Buira

Department of Pathology, IIS “Fundacion Jimenez Diaz University Hospital,” Madrid, Spain.

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Federico Rojo

Department of Pathology, IIS “Fundacion Jimenez Diaz University Hospital,” Madrid, Spain.

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Marcel Costa-García

Universitat Pompeu Fabra, Barcelona, Spain.

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Oriol Arpí

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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Manuela Moraru

HLA-Immunogenetics Department, Instituto Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

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Laia Serrano

Department of Pathology, Hospital del Mar, Barcelona, Spain.

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Ignasi Tusquets

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Department of Medical Oncology, Hospital del Mar-CIBERONC, Barcelona, Spain.

Universitat Pompeu Fabra, Barcelona, Spain.

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María Teresa Martínez

Department of Oncology, Hospital Clinico de Valencia-CIBERONC, Valencia, Spain.

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Gemma Heredia

Universitat Pompeu Fabra, Barcelona, Spain.

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Andrea Vera

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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María Martínez-García

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Department of Medical Oncology, Hospital del Mar-CIBERONC, Barcelona, Spain.

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Laura Soria

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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Laura Comerma

Department of Pathology, Hospital del Mar, Barcelona, Spain.

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Sara Santana-Hernández

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

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Pilar Eroles

Department of Oncology, Hospital Clinico de Valencia-CIBERONC, Valencia, Spain.

Biomedical Research Institute, INCLIVA, Valencia, Spain.

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Ana Rovira

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Department of Medical Oncology, Hospital del Mar-CIBERONC, Barcelona, Spain.

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Carlos Vilches

HLA-Immunogenetics Department, Instituto Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

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Ana Lluch

Department of Oncology, Hospital Clinico de Valencia-CIBERONC, Valencia, Spain.

Biomedical Research Institute, INCLIVA, Valencia, Spain.

Universitat de Valencia, Valencia, Spain.

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Joan Albanell

Cancer Research Program, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Department of Medical Oncology, Hospital del Mar-CIBERONC, Barcelona, Spain.

Universitat Pompeu Fabra, Barcelona, Spain.

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For correspondence: amuntasell@imim.es jalbanell@hospitaldelmar.cat

Miguel López-Botet

Immunity and Infection, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Barcelona, Spain.

Universitat Pompeu Fabra, Barcelona, Spain.

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ORCID record for Miguel López-Botet

DOI: 10.1158/2326-6066.CIR-18-0896 Published August 2019

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August 2019
Volume 7, Issue 8

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High Numbers of Circulating CD57⁺ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2⁺ Primary Breast Cancer