IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Lulu Shao; Weizhou Hou; Nicole E. Scharping; Frank P. Vendetti; Rashmi Srivastava; Chandra Nath Roy; Ashley V. Menk; Yiyang Wang; Joe-Marc Chauvin; Pooja Karukonda; Stephen H. Thorne; Veit Hornung; Hassane M. Zarour; Christopher J. Bakkenist; Greg M. Delgoffe; Saumendra N. Sarkar

doi:10.1158/2326-6066.CIR-18-0711

Research Articles

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Lulu Shao, Weizhou Hou, Nicole E. Scharping, Frank P. Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V. Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H. Thorne, Veit Hornung, Hassane M. Zarour, Christopher J. Bakkenist, Greg M. Delgoffe and Saumendra N. Sarkar

Lulu Shao

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Weizhou Hou

Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

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Nicole E. Scharping

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Frank P. Vendetti

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Rashmi Srivastava

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Chandra Nath Roy

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Ashley V. Menk

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Yiyang Wang

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Joe-Marc Chauvin

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Pooja Karukonda

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Stephen H. Thorne

Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

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Veit Hornung

Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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Hassane M. Zarour

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Christopher J. Bakkenist

Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Greg M. Delgoffe

Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Saumendra N. Sarkar

Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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For correspondence: saumen@pitt.edu

DOI: 10.1158/2326-6066.CIR-18-0711 Published August 2019

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August 2019
Volume 7, Issue 8

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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell