IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Lulu Shao; Weizhou Hou; Nicole E. Scharping; Frank P. Vendetti; Rashmi Srivastava; Chandra Nath Roy; Ashley V. Menk; Yiyang Wang; Joe-Marc Chauvin; Pooja Karukonda; Stephen H. Thorne; Veit Hornung; Hassane M. Zarour; Christopher J. Bakkenist; Greg M. Delgoffe; Saumendra N. Sarkar

doi:10.1158/2326-6066.CIR-18-0711

Research Articles

IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Lulu Shao, Weizhou Hou, Nicole E. Scharping, Frank P. Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V. Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H. Thorne, Veit Hornung, Hassane M. Zarour, Christopher J. Bakkenist, Greg M. Delgoffe and Saumendra N. Sarkar

Lulu Shao

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Weizhou Hou

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

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Nicole E. Scharping

3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Frank P. Vendetti

5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Rashmi Srivastava

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Chandra Nath Roy

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Ashley V. Menk

3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Yiyang Wang

3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Joe-Marc Chauvin

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Pooja Karukonda

5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Stephen H. Thorne

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

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Veit Hornung

6Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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Hassane M. Zarour

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Christopher J. Bakkenist

5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Greg M. Delgoffe

3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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Saumendra N. Sarkar

1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.

2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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For correspondence: saumen@pitt.edu

DOI: 10.1158/2326-6066.CIR-18-0711 Published August 2019

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August 2019
Volume 7, Issue 8

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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Cancer Immunol Res August 1 2019 (7) (8) 1258-1266; DOI: 10.1158/2326-6066.CIR-18-0711

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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Cancer Immunol Res August 1 2019 (7) (8) 1258-1266; DOI: 10.1158/2326-6066.CIR-18-0711

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