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Cancer Immunology Research
Cancer Immunology Research
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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell

Lulu Shao, Weizhou Hou, Nicole E. Scharping, Frank P. Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V. Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H. Thorne, Veit Hornung, Hassane M. Zarour, Christopher J. Bakkenist, Greg M. Delgoffe and Saumendra N. Sarkar
Lulu Shao
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Weizhou Hou
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
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Nicole E. Scharping
3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Frank P. Vendetti
5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Rashmi Srivastava
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Chandra Nath Roy
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Ashley V. Menk
3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Yiyang Wang
3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Joe-Marc Chauvin
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Pooja Karukonda
5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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  • ORCID record for Pooja Karukonda
Stephen H. Thorne
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
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Veit Hornung
6Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
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Hassane M. Zarour
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Christopher J. Bakkenist
5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Greg M. Delgoffe
3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Saumendra N. Sarkar
1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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  • For correspondence: saumen@pitt.edu
DOI: 10.1158/2326-6066.CIR-18-0711 Published August 2019
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Article Information

Volume 7, Issue 8, pp. 1258-1266

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0711
PubMed 
31239318

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received October 4, 2018
  • Revision received March 29, 2019
  • Accepted June 19, 2019
  • Published first June 25, 2019.

Article Versions

  • Previous version (June 25, 2019 - 06:56).
  • Previous version (July 11, 2019 - 05:54).
  • You are viewing the most recent version of this article.
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©2019 American Association for Cancer Research.

Author Information

  1. Lulu Shao1,2,
  2. Weizhou Hou1,
  3. Nicole E. Scharping3,4,
  4. Frank P. Vendetti5,
  5. Rashmi Srivastava1,2,
  6. Chandra Nath Roy1,2,
  7. Ashley V. Menk3,4,
  8. Yiyang Wang3,4,
  9. Joe-Marc Chauvin4,
  10. Pooja Karukonda5,
  11. Stephen H. Thorne1,
  12. Veit Hornung6,
  13. Hassane M. Zarour4,
  14. Christopher J. Bakkenist5,
  15. Greg M. Delgoffe3,4, and
  16. Saumendra N. Sarkar1,2,4,*
  1. 1Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
  2. 2Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  3. 3Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
  4. 4Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  5. 5Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
  6. 6Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
  1. ↵*Corresponding Author:
    Saumendra N. Sarkar, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, UPMC Hillman Cancer Center, Suite 1.8, Pittsburgh, PA 15213. Phone: 412-623-7720; Fax: 412-623-7715; E-mail: saumen{at}pitt.edu
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Cancer Immunology Research: 7 (8)
August 2019
Volume 7, Issue 8
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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell
Lulu Shao, Weizhou Hou, Nicole E. Scharping, Frank P. Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V. Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H. Thorne, Veit Hornung, Hassane M. Zarour, Christopher J. Bakkenist, Greg M. Delgoffe and Saumendra N. Sarkar
Cancer Immunol Res August 1 2019 (7) (8) 1258-1266; DOI: 10.1158/2326-6066.CIR-18-0711

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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell
Lulu Shao, Weizhou Hou, Nicole E. Scharping, Frank P. Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V. Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H. Thorne, Veit Hornung, Hassane M. Zarour, Christopher J. Bakkenist, Greg M. Delgoffe and Saumendra N. Sarkar
Cancer Immunol Res August 1 2019 (7) (8) 1258-1266; DOI: 10.1158/2326-6066.CIR-18-0711
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