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Cancer Immunology Research
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Research Articles

Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis

Cathal Harmon, Mark W. Robinson, Fiona Hand, Dalal Almuaili, Keno Mentor, Diarmaid D. Houlihan, Emir Hoti, Lydia Lynch, Justin Geoghegan and Cliona O'Farrelly
Cathal Harmon
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
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  • ORCID record for Cathal Harmon
Mark W. Robinson
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
2School of Medicine, Trinity College Dublin, Dublin, Ireland.
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Fiona Hand
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
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Dalal Almuaili
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
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Keno Mentor
3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
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Diarmaid D. Houlihan
3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
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Emir Hoti
3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
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Lydia Lynch
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
4Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Justin Geoghegan
3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
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Cliona O'Farrelly
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
2School of Medicine, Trinity College Dublin, Dublin, Ireland.
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  • For correspondence: OFARRECL@tcd.ie
DOI: 10.1158/2326-6066.CIR-18-0481 Published February 2019
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ARTICLE USAGE: December 2018 to January 2021

AbstractFull-text HTMLPDF
Total377214101371

Cited By

Article Information

Volume 7, Issue 2, pp. 335-346

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0481
PubMed 
30563827

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received July 18, 2018
  • Revision received October 6, 2018
  • Accepted December 14, 2018
  • Published first December 18, 2018.

Article Versions

  • Previous version (December 18, 2018 - 07:17).
  • Previous version (January 23, 2019 - 09:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Cathal Harmon1,
  2. Mark W. Robinson1,2,
  3. Fiona Hand1,3,
  4. Dalal Almuaili1,
  5. Keno Mentor3,
  6. Diarmaid D. Houlihan3,
  7. Emir Hoti3,
  8. Lydia Lynch1,4,
  9. Justin Geoghegan3, and
  10. Cliona O'Farrelly1,2,*
  1. 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  2. 2School of Medicine, Trinity College Dublin, Dublin, Ireland.
  3. 3Liver Unit, St. Vincent's University Hospital, Dublin, Ireland.
  4. 4Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Cliona O'Farrelly, Trinity College Dublin, Dublin, D02 R590, Ireland. Phone: 353-1896-3175; Fax: 353-1677-2400; E-mail: OFARRECL{at}tcd.ie
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Cancer Immunology Research: 7 (2)
February 2019
Volume 7, Issue 2
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Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis
Cathal Harmon, Mark W. Robinson, Fiona Hand, Dalal Almuaili, Keno Mentor, Diarmaid D. Houlihan, Emir Hoti, Lydia Lynch, Justin Geoghegan and Cliona O'Farrelly
Cancer Immunol Res February 1 2019 (7) (2) 335-346; DOI: 10.1158/2326-6066.CIR-18-0481

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Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis
Cathal Harmon, Mark W. Robinson, Fiona Hand, Dalal Almuaili, Keno Mentor, Diarmaid D. Houlihan, Emir Hoti, Lydia Lynch, Justin Geoghegan and Cliona O'Farrelly
Cancer Immunol Res February 1 2019 (7) (2) 335-346; DOI: 10.1158/2326-6066.CIR-18-0481
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