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Cancer Immunology Research
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Mouse PVRIG Has CD8+ T Cell–Specific Coinhibitory Functions and Dampens Antitumor Immunity

Benjamin Murter, Xiaoyu Pan, Eran Ophir, Zoya Alteber, Meir Azulay, Rupashree Sen, Ofer Levy, Liat Dassa, Ilan Vaknin, Tal Fridman-Kfir, Ran Salomon, Achinoam Ravet, Ada Tam, Doron Levin, Yakir Vaknin, Evgeny Tatirovsky, Arthur Machlenkin, Drew Pardoll and Sudipto Ganguly
Benjamin Murter
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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Xiaoyu Pan
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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Eran Ophir
2Compugen Ltd, Holon, Israel.
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Zoya Alteber
2Compugen Ltd, Holon, Israel.
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Meir Azulay
2Compugen Ltd, Holon, Israel.
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Rupashree Sen
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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Ofer Levy
2Compugen Ltd, Holon, Israel.
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Liat Dassa
2Compugen Ltd, Holon, Israel.
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Ilan Vaknin
2Compugen Ltd, Holon, Israel.
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Tal Fridman-Kfir
2Compugen Ltd, Holon, Israel.
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Ran Salomon
2Compugen Ltd, Holon, Israel.
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Achinoam Ravet
2Compugen Ltd, Holon, Israel.
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Ada Tam
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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Doron Levin
2Compugen Ltd, Holon, Israel.
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Yakir Vaknin
2Compugen Ltd, Holon, Israel.
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Evgeny Tatirovsky
2Compugen Ltd, Holon, Israel.
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Arthur Machlenkin
2Compugen Ltd, Holon, Israel.
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Drew Pardoll
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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Sudipto Ganguly
1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
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  • ORCID record for Sudipto Ganguly
  • For correspondence: sgangul8@jhmi.edu
DOI: 10.1158/2326-6066.CIR-18-0460 Published February 2019
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AbstractFull-text HTMLPDF
Total34261244936

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Article Information

Volume 7, Issue 2, pp. 244-256

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0460
PubMed 
30659055

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received July 7, 2018
  • Revision received October 2, 2018
  • Accepted December 3, 2018
  • Published first January 18, 2019.

Article Versions

  • Previous version (January 18, 2019 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. Benjamin Murter1,
  2. Xiaoyu Pan1,
  3. Eran Ophir2,
  4. Zoya Alteber2,
  5. Meir Azulay2,
  6. Rupashree Sen1,
  7. Ofer Levy2,
  8. Liat Dassa2,
  9. Ilan Vaknin2,
  10. Tal Fridman-Kfir2,
  11. Ran Salomon2,
  12. Achinoam Ravet2,
  13. Ada Tam1,
  14. Doron Levin2,
  15. Yakir Vaknin2,
  16. Evgeny Tatirovsky2,
  17. Arthur Machlenkin2,
  18. Drew Pardoll1, and
  19. Sudipto Ganguly1,*
  1. 1Bloomberg–Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University, Baltimore, Maryland.
  2. 2Compugen Ltd, Holon, Israel.
  1. ↵*Corresponding Author:
    Sudipto Ganguly, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB-1 Room 441, Baltimore, MD 21287. Phone: 410-614-2948; E-mail: sgangul8{at}jhmi.edu
  1. B. Murter and X. Pan contributed equally to this article.

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Cancer Immunology Research: 7 (2)
February 2019
Volume 7, Issue 2
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Mouse PVRIG Has CD8+ T Cell–Specific Coinhibitory Functions and Dampens Antitumor Immunity
Benjamin Murter, Xiaoyu Pan, Eran Ophir, Zoya Alteber, Meir Azulay, Rupashree Sen, Ofer Levy, Liat Dassa, Ilan Vaknin, Tal Fridman-Kfir, Ran Salomon, Achinoam Ravet, Ada Tam, Doron Levin, Yakir Vaknin, Evgeny Tatirovsky, Arthur Machlenkin, Drew Pardoll and Sudipto Ganguly
Cancer Immunol Res February 1 2019 (7) (2) 244-256; DOI: 10.1158/2326-6066.CIR-18-0460

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Mouse PVRIG Has CD8+ T Cell–Specific Coinhibitory Functions and Dampens Antitumor Immunity
Benjamin Murter, Xiaoyu Pan, Eran Ophir, Zoya Alteber, Meir Azulay, Rupashree Sen, Ofer Levy, Liat Dassa, Ilan Vaknin, Tal Fridman-Kfir, Ran Salomon, Achinoam Ravet, Ada Tam, Doron Levin, Yakir Vaknin, Evgeny Tatirovsky, Arthur Machlenkin, Drew Pardoll and Sudipto Ganguly
Cancer Immunol Res February 1 2019 (7) (2) 244-256; DOI: 10.1158/2326-6066.CIR-18-0460
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