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Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition

Hussein Sultan, Takumi Kumai, Valentyna I. Fesenkova, Aaron E. Fan, Juan Wu, Hyun-Il Cho, Hiroya Kobayashi, Yasuaki Harabuchi and Esteban Celis
Hussein Sultan
1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
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Takumi Kumai
2Department of Pathology, Asahikawa Medical University, Asahikawa, Japan.
3Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.
4Department of Innovative Research for Diagnosis and Treatment of Head and Neck Cancer, Asahikawa Medical University, Asahikawa, Japan.
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Valentyna I. Fesenkova
1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
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Aaron E. Fan
1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
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Juan Wu
1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
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Hyun-Il Cho
5Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Hiroya Kobayashi
2Department of Pathology, Asahikawa Medical University, Asahikawa, Japan.
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Yasuaki Harabuchi
3Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.
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Esteban Celis
1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
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  • For correspondence: ecelis@augusta.edu
DOI: 10.1158/2326-6066.CIR-17-0549 Published May 2018
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Article Information

Volume 6, Issue 5, pp. 617-627

DOI 
https://doi.org/10.1158/2326-6066.CIR-17-0549
PubMed 
29483127

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received September 27, 2017
  • Revision received January 9, 2018
  • Accepted February 22, 2018
  • Published first February 26, 2018.

Article Versions

  • Previous version (February 26, 2018 - 07:40).
  • Previous version (February 27, 2018 - 07:18).
  • Previous version (April 9, 2018 - 07:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Hussein Sultan1,
  2. Takumi Kumai2,3,4,
  3. Valentyna I. Fesenkova1,
  4. Aaron E. Fan1,
  5. Juan Wu1,
  6. Hyun-Il Cho5,
  7. Hiroya Kobayashi2,
  8. Yasuaki Harabuchi3, and
  9. Esteban Celis1,*
  1. 1Cancer Immunology, Inflammation and Tolerance Program, Augusta University Georgia Cancer Center, Augusta, Georgia.
  2. 2Department of Pathology, Asahikawa Medical University, Asahikawa, Japan.
  3. 3Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.
  4. 4Department of Innovative Research for Diagnosis and Treatment of Head and Neck Cancer, Asahikawa Medical University, Asahikawa, Japan.
  5. 5Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  1. ↵*Corresponding Author:
    Esteban Celis, Augusta University, 1410 Laney Walker Boulevard, CN4121, Augusta, GA 30912. Phone: 706-721-5668; Fax: 706-721-1670; E-mail: ecelis{at}augusta.edu
  1. H. Sultan, T. Kumai, and V.I. Fesenkova contributed equally to this article.

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Cancer Immunology Research: 6 (5)
May 2018
Volume 6, Issue 5
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Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition
Hussein Sultan, Takumi Kumai, Valentyna I. Fesenkova, Aaron E. Fan, Juan Wu, Hyun-Il Cho, Hiroya Kobayashi, Yasuaki Harabuchi and Esteban Celis
Cancer Immunol Res May 1 2018 (6) (5) 617-627; DOI: 10.1158/2326-6066.CIR-17-0549

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Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition
Hussein Sultan, Takumi Kumai, Valentyna I. Fesenkova, Aaron E. Fan, Juan Wu, Hyun-Il Cho, Hiroya Kobayashi, Yasuaki Harabuchi and Esteban Celis
Cancer Immunol Res May 1 2018 (6) (5) 617-627; DOI: 10.1158/2326-6066.CIR-17-0549
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