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Cancer Immunology Research
Cancer Immunology Research
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About the Cover

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About the Cover
Regulatory T cells contribute to the protumor environment in cancer. Large numbers in tumors, or a high regulatory T:CD8+ T cell ratio, is associated with a poor prognosis. However, that relationship is not always found in urinary bladder cancer. Winerdal et al. first established that the regulatory T cells in human bladder cancers are functionally suppressive like other regulatory T cells. They then observed that these regulatory T cells suppressed tumor and macrophage production of MMP2, a metalloproteinase that aids metastasis. Thus, higher numbers of regulatory T cells congregating at the invasive front of a tumor correlated with survival. Read more in this issue on page 528. Original micrograph from the Winqvist laboratory shows a bladder tumor infiltrated and surrounded by brown T cells, some of which are regulatory. Artwork by Lewis Long.

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Cancer Immunology Research: 6 (5)
May 2018
Volume 6, Issue 5
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Cancer Immunology Research
eISSN: 2326-6074
ISSN: 2326-6066

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