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Cancer Immunology Research
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TUSC2 Immunogene Therapy Synergizes with Anti–PD-1 through Enhanced Proliferation and Infiltration of Natural Killer Cells in Syngeneic Kras-Mutant Mouse Lung Cancer Models

Ismail M. Meraz, Mourad Majidi, Xiaobo Cao, Heather Lin, Lerong Li, Jing Wang, Veera Baladandayuthapani, David Rice, Boris Sepesi, Lin Ji and Jack A. Roth
Ismail M. Meraz
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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  • For correspondence: imeraz@mdanderson.org
Mourad Majidi
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Xiaobo Cao
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Heather Lin
2Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Lerong Li
3Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Jing Wang
3Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Veera Baladandayuthapani
2Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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David Rice
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Boris Sepesi
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Lin Ji
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Jack A. Roth
1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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DOI: 10.1158/2326-6066.CIR-17-0273 Published February 2018
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Article Information

Volume 6, Issue 2, pp. 163-177

DOI 
https://doi.org/10.1158/2326-6066.CIR-17-0273
PubMed 
29339375

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received May 30, 2017
  • Revision received September 27, 2017
  • Accepted December 21, 2017
  • Published first January 16, 2018.

Article Versions

  • Previous version (January 16, 2018 - 06:02).
  • Previous version (January 23, 2018 - 07:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Ismail M. Meraz1,*,
  2. Mourad Majidi1,
  3. Xiaobo Cao1,
  4. Heather Lin2,
  5. Lerong Li3,
  6. Jing Wang3,
  7. Veera Baladandayuthapani2,
  8. David Rice1,
  9. Boris Sepesi1,
  10. Lin Ji1, and
  11. Jack A. Roth1
  1. 1Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  2. 2Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  3. 3Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  1. ↵*Corresponding Author:
    Ismail M. Meraz, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Room Number T4.3986A, Houston, TX 77030. Phone: 713-794-1960; E-mail: imeraz{at}mdanderson.org
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Cancer Immunology Research: 6 (2)
February 2018
Volume 6, Issue 2
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TUSC2 Immunogene Therapy Synergizes with Anti–PD-1 through Enhanced Proliferation and Infiltration of Natural Killer Cells in Syngeneic Kras-Mutant Mouse Lung Cancer Models
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TUSC2 Immunogene Therapy Synergizes with Anti–PD-1 through Enhanced Proliferation and Infiltration of Natural Killer Cells in Syngeneic Kras-Mutant Mouse Lung Cancer Models
Ismail M. Meraz, Mourad Majidi, Xiaobo Cao, Heather Lin, Lerong Li, Jing Wang, Veera Baladandayuthapani, David Rice, Boris Sepesi, Lin Ji and Jack A. Roth
Cancer Immunol Res February 1 2018 (6) (2) 163-177; DOI: 10.1158/2326-6066.CIR-17-0273

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TUSC2 Immunogene Therapy Synergizes with Anti–PD-1 through Enhanced Proliferation and Infiltration of Natural Killer Cells in Syngeneic Kras-Mutant Mouse Lung Cancer Models
Ismail M. Meraz, Mourad Majidi, Xiaobo Cao, Heather Lin, Lerong Li, Jing Wang, Veera Baladandayuthapani, David Rice, Boris Sepesi, Lin Ji and Jack A. Roth
Cancer Immunol Res February 1 2018 (6) (2) 163-177; DOI: 10.1158/2326-6066.CIR-17-0273
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