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Cancer Immunology Research
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NK Cell Education in Tumor Immune Surveillance: DNAM-1/KIR Receptor Ratios as Predictive Biomarkers for Solid Tumor Outcome

Concepción F. Guillamón, María V. Martínez-Sánchez, Lourdes Gimeno, Anna Mrowiec, Jerónimo Martínez-García, Gerardo Server-Pastor, Jorge Martínez-Escribano, Amparo Torroba, Belén Ferri, Daniel Abellán, José A. Campillo, Isabel Legaz, María R. López-Álvarez, María Rosa Moya-Quiles, Manuel Muro and Alfredo Minguela
Concepción F. Guillamón
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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María V. Martínez-Sánchez
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Lourdes Gimeno
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Anna Mrowiec
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Jerónimo Martínez-García
2Oncology, HCUVA, Murcia, Spain.
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Gerardo Server-Pastor
3Urology, HCUVA, Murcia, Spain.
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Jorge Martínez-Escribano
4Dermatology, HCUVA, Murcia, Spain.
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Amparo Torroba
5Pathology Services, HCUVA, Murcia, Spain.
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Belén Ferri
5Pathology Services, HCUVA, Murcia, Spain.
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Daniel Abellán
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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José A. Campillo
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Isabel Legaz
6Forensic Medicine, Universidad de Murcia, Murcia, Spain.
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  • ORCID record for Isabel Legaz
María R. López-Álvarez
7Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, United Kingdom.
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  • ORCID record for María R. López-Álvarez
María Rosa Moya-Quiles
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Manuel Muro
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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Alfredo Minguela
1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
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  • For correspondence: alfredo.minguela@carm.es
DOI: 10.1158/2326-6066.CIR-18-0022 Published December 2018
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ARTICLE USAGE: September 2018 to March 2021

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Article Information

Volume 6, Issue 12, pp. 1537-1547

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0022
PubMed 
30242020

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received March 6, 2018
  • Revision received June 15, 2018
  • Accepted September 17, 2018
  • Published first September 21, 2018.

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  • Previous version (September 21, 2018 - 06:49).
  • Previous version (October 30, 2018 - 07:14).
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©2018 American Association for Cancer Research.

Author Information

  1. Concepción F. Guillamón1,
  2. María V. Martínez-Sánchez1,
  3. Lourdes Gimeno1,
  4. Anna Mrowiec1,
  5. Jerónimo Martínez-García2,
  6. Gerardo Server-Pastor3,
  7. Jorge Martínez-Escribano4,
  8. Amparo Torroba5,
  9. Belén Ferri5,
  10. Daniel Abellán1,
  11. José A. Campillo1,
  12. Isabel Legaz6,
  13. María R. López-Álvarez7,
  14. María Rosa Moya-Quiles1,
  15. Manuel Muro1, and
  16. Alfredo Minguela1,*
  1. 1Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain.
  2. 2Oncology, HCUVA, Murcia, Spain.
  3. 3Urology, HCUVA, Murcia, Spain.
  4. 4Dermatology, HCUVA, Murcia, Spain.
  5. 5Pathology Services, HCUVA, Murcia, Spain.
  6. 6Forensic Medicine, Universidad de Murcia, Murcia, Spain.
  7. 7Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, United Kingdom.
  1. ↵*Corresponding Author:
    Alfredo Minguela, Servicio de Inmunología, Virgen de la Arrixaca University Hospital Ctra. Madrid-Cartagena, El Palmar, 30120-Murcia, Spain. Phone: 349-683-95379; E-mail: alfredo.minguela{at}carm.es
  1. C.F. Guillamón, M.V. Martínez-Sánchez, and L. Gimeno contributed equally to this article.

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Cancer Immunology Research: 6 (12)
December 2018
Volume 6, Issue 12
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NK Cell Education in Tumor Immune Surveillance: DNAM-1/KIR Receptor Ratios as Predictive Biomarkers for Solid Tumor Outcome
Concepción F. Guillamón, María V. Martínez-Sánchez, Lourdes Gimeno, Anna Mrowiec, Jerónimo Martínez-García, Gerardo Server-Pastor, Jorge Martínez-Escribano, Amparo Torroba, Belén Ferri, Daniel Abellán, José A. Campillo, Isabel Legaz, María R. López-Álvarez, María Rosa Moya-Quiles, Manuel Muro and Alfredo Minguela
Cancer Immunol Res December 1 2018 (6) (12) 1537-1547; DOI: 10.1158/2326-6066.CIR-18-0022

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NK Cell Education in Tumor Immune Surveillance: DNAM-1/KIR Receptor Ratios as Predictive Biomarkers for Solid Tumor Outcome
Concepción F. Guillamón, María V. Martínez-Sánchez, Lourdes Gimeno, Anna Mrowiec, Jerónimo Martínez-García, Gerardo Server-Pastor, Jorge Martínez-Escribano, Amparo Torroba, Belén Ferri, Daniel Abellán, José A. Campillo, Isabel Legaz, María R. López-Álvarez, María Rosa Moya-Quiles, Manuel Muro and Alfredo Minguela
Cancer Immunol Res December 1 2018 (6) (12) 1537-1547; DOI: 10.1158/2326-6066.CIR-18-0022
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