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Cancer Immunology Research
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Research Articles

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing

Patrick H. Lizotte, Ruey-Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Meghana Kulkarni, Lauren Badalucco, Erica Fitzpatrick, Hsiang-Fong Kao, Mari Kuraguchi, Mark Bittinger, Paul T. Kirschmeier, Nathanael S. Gray, David A. Barbie and Pasi A. Jänne
Patrick H. Lizotte
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • ORCID record for Patrick H. Lizotte
Ruey-Long Hong
3Department of Oncology, National Taiwan University Hospital, Zhongzheng District, Taipei City, Taiwan.
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Troy A. Luster
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Megan E. Cavanaugh
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Luke J. Taus
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Stephen Wang
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Abha Dhaneshwar
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Naomi Mayman
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Aaron Yang
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Meghana Kulkarni
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Lauren Badalucco
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Erica Fitzpatrick
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • ORCID record for Erica Fitzpatrick
Hsiang-Fong Kao
3Department of Oncology, National Taiwan University Hospital, Zhongzheng District, Taipei City, Taiwan.
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Mari Kuraguchi
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Mark Bittinger
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Paul T. Kirschmeier
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Nathanael S. Gray
4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
5Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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David A. Barbie
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
6Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Pasi A. Jänne
1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
6Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • For correspondence: Pasi_Janne@dfci.harvard.edu
DOI: 10.1158/2326-6066.CIR-18-0193 Published December 2018
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ARTICLE USAGE: September 2018 to March 2021

AbstractFull-text HTMLPDF
Total500638523832

Cited By

Article Information

Volume 6, Issue 12, pp. 1511-1523

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0193
PubMed 
30242021

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received March 29, 2018
  • Revision received July 18, 2018
  • Accepted September 14, 2018
  • Published first September 21, 2018.

Article Versions

  • Previous version (September 21, 2018 - 06:49).
  • Previous version (October 5, 2018 - 06:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Patrick H. Lizotte1,2,
  2. Ruey-Long Hong3,
  3. Troy A. Luster1,2,
  4. Megan E. Cavanaugh1,2,
  5. Luke J. Taus1,2,
  6. Stephen Wang1,2,
  7. Abha Dhaneshwar1,2,
  8. Naomi Mayman1,2,
  9. Aaron Yang1,2,
  10. Meghana Kulkarni1,2,
  11. Lauren Badalucco1,2,
  12. Erica Fitzpatrick1,2,
  13. Hsiang-Fong Kao3,
  14. Mari Kuraguchi1,2,
  15. Mark Bittinger1,2,
  16. Paul T. Kirschmeier1,2,
  17. Nathanael S. Gray4,5,
  18. David A. Barbie1,2,6, and
  19. Pasi A. Jänne1,2,6,*
  1. 1Belfer Center for Applied Cancer Science, Boston, Massachusetts.
  2. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  3. 3Department of Oncology, National Taiwan University Hospital, Zhongzheng District, Taipei City, Taiwan.
  4. 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  5. 5Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
  6. 6Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Author:
    Pasi A. Jänne, Dana-Farber Cancer Institute, 450 Brookline Avenue, LC-4114,Boston, MA 02215. Phone: 617-632-6076; Fax: 617-582-7683; E-mail: Pasi_Janne{at}dfci.harvard.edu
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Cancer Immunology Research: 6 (12)
December 2018
Volume 6, Issue 12
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A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing
Patrick H. Lizotte, Ruey-Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Meghana Kulkarni, Lauren Badalucco, Erica Fitzpatrick, Hsiang-Fong Kao, Mari Kuraguchi, Mark Bittinger, Paul T. Kirschmeier, Nathanael S. Gray, David A. Barbie and Pasi A. Jänne
Cancer Immunol Res December 1 2018 (6) (12) 1511-1523; DOI: 10.1158/2326-6066.CIR-18-0193

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A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing
Patrick H. Lizotte, Ruey-Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Meghana Kulkarni, Lauren Badalucco, Erica Fitzpatrick, Hsiang-Fong Kao, Mari Kuraguchi, Mark Bittinger, Paul T. Kirschmeier, Nathanael S. Gray, David A. Barbie and Pasi A. Jänne
Cancer Immunol Res December 1 2018 (6) (12) 1511-1523; DOI: 10.1158/2326-6066.CIR-18-0193
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