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Cancer Immunology Research
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Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms

Jinming Yang, Amrendra Kumar, Anna E. Vilgelm, Sheau-Chiann Chen, Gregory D. Ayers, Sergey V. Novitskiy, Sebastian Joyce and Ann Richmond
Jinming Yang
1Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee.
2Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
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Amrendra Kumar
1Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee.
3Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
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Anna E. Vilgelm
2Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
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Sheau-Chiann Chen
4Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
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  • ORCID record for Sheau-Chiann Chen
Gregory D. Ayers
4Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
5Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University, Nashville, Tennessee.
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Sergey V. Novitskiy
6Department of Medicine, Vanderbilt University, Nashville, Tennessee.
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Sebastian Joyce
1Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee.
3Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
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Ann Richmond
1Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee.
2Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
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  • For correspondence: ann.richmond@vanderbilt.edu
DOI: 10.1158/2326-6066.CIR-18-0045 Published October 2018
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Cited By

Article Information

Volume 6, Issue 10, pp. 1186-1198

DOI 
https://doi.org/10.1158/2326-6066.CIR-18-0045
PubMed 
30108045

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received February 7, 2018
  • Revision received June 7, 2018
  • Accepted August 9, 2018
  • Published first August 14, 2018.

Article Versions

  • Previous version (August 14, 2018 - 06:53).
  • Previous version (August 31, 2018 - 06:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Jinming Yang1,2,
  2. Amrendra Kumar1,3,
  3. Anna E. Vilgelm2,
  4. Sheau-Chiann Chen4,
  5. Gregory D. Ayers4,5,
  6. Sergey V. Novitskiy6,
  7. Sebastian Joyce1,3, and
  8. Ann Richmond1,2,*
  1. 1Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee.
  2. 2Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.
  3. 3Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
  4. 4Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
  5. 5Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University, Nashville, Tennessee.
  6. 6Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  1. ↵*Corresponding Author:
    Ann Richmond, Vanderbilt University, PRB432, 2220 Pierce Avenue, Nashville, TN 37232. Phone: 615–343–7777; Fax: 615–936–2911; E-mail: ann.richmond{at}vanderbilt.edu
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Cancer Immunology Research: 6 (10)
October 2018
Volume 6, Issue 10
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Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms
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Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms
Jinming Yang, Amrendra Kumar, Anna E. Vilgelm, Sheau-Chiann Chen, Gregory D. Ayers, Sergey V. Novitskiy, Sebastian Joyce and Ann Richmond
Cancer Immunol Res October 1 2018 (6) (10) 1186-1198; DOI: 10.1158/2326-6066.CIR-18-0045

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Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms
Jinming Yang, Amrendra Kumar, Anna E. Vilgelm, Sheau-Chiann Chen, Gregory D. Ayers, Sergey V. Novitskiy, Sebastian Joyce and Ann Richmond
Cancer Immunol Res October 1 2018 (6) (10) 1186-1198; DOI: 10.1158/2326-6066.CIR-18-0045
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