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Synovial sarcoma primarily strikes adolescents and young adults, with particularly devastating results. Vaccination trials show some promise, which implies that these sarcomas may be immunologically competent. Nowicki et al. have examined metastatic tumors from synovial sarcoma patients and found that not only do many of the sarcomas contain CD8⁺ T cells, but PD-1 and PD-L1 staining often coincides with the T cells at the invasive margins of the tumors, as shown in the micrograph on the right. Thus, inhibiting the PD-1/PD-L1 axis with checkpoint blockade may be potentially useful in treating this cancer. Read more in the article by Nowicki et al. in this issue of Cancer Immunology Research, starting on page 118. Immunofluorescence micrograph is from Fig. 4 and artwork is by Lewis Long.