Table of Contents

Research Articles

• Research Articles

  Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes

  Andres Forero, Yufeng Li, Dongquan Chen, William E. Grizzle, Katherine L. Updike, Natalie D. Merz, Erinn Downs-Kelly, Todd C. Burwell, Christos Vaklavas, Donald J. Buchsbaum, Richard M. Myers, Albert F. LoBuglio and Katherine E. Varley

  Cancer Immunol Res May 1 2016 4 (5) 390-399; DOI:10.1158/2326-6066.CIR-15-0243

  
  

  The MHC II pathway is usually turned off in tumor cells. Expression in triple-negative breast tumors was correlated with antitumor responses and reduced relapse risk. MHC II expression may predict good prognosis, and inducing it may have therapeutic benefits.

• Research Articles

  IFNγ-Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2–Mediated Inhibition of Antitumor CTL Responses

  Fatemah Salem Basingab, Maryam Ahmadi and David John Morgan

  Cancer Immunol Res May 1 2016 4 (5) 400-411; DOI:10.1158/2326-6066.CIR-15-0146

  
  

  Robust antitumor CTL responses require adhesion of the killer cell to tumor cells. PGE2 suppresses CTL function, but this could be overcome by the IFNγ-induced upregulation of ICAM-1, which drove CTL generation and limited tumor growth in vivo.

• Research Articles

  TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination

  Melody S. Hsu, Shaina Sedighim, Tina Wang, Joseph P. Antonios, Richard G. Everson, Alexander M. Tucker, Lin Du, Ryan Emerson, Erik Yusko, Catherine Sanders, Harlan S. Robins, William H. Yong, Tom B. Davidson, Gang Li, Linda M. Liau and Robert M. Prins

  Cancer Immunol Res May 1 2016 4 (5) 412-418; DOI:10.1158/2326-6066.CIR-15-0240

  
  

  A clinically translatable platform was developed to track T-cell populations without prior knowledge of their specificity. TCR sequencing data could be used to distinguish patients with glioblastoma who will benefit and are benefitting from immunotherapy.

• Research Articles

  Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

  Andrew Gabrielson, Yunan Wu, Hongkun Wang, Jiji Jiang, Bhaskar Kallakury, Zoran Gatalica, Sandeep Reddy, David Kleiner, Thomas Fishbein, Lynt Johnson, Eddie Island, Rohit Satoskar, Filip Banovac, Reena Jha, Jaydeep Kachhela, Perry Feng, Tiger Zhang, Anteneh Tesfaye, Petra Prins, Christopher Loffredo, John Marshall, Louis Weiner, Michael Atkins and Aiwu Ruth He

  Cancer Immunol Res May 1 2016 4 (5) 419-430; DOI:10.1158/2326-6066.CIR-15-0110

  
  

  Tumor immune infiltration is a prognostic marker for relapse in patients with colorectal cancer. The Immunoscore methodology was extended to patients with hepatocellular carcinoma. The Immunoscore could predict the risk of postsurgical relapse and duration of relapse-free survival.

• Research Articles

  Broadening Specificity and Enhancing Cytotoxicity of Adoptive T Cells for Nasopharyngeal Carcinoma Immunotherapy

  Damiana Antonia Faè, Debora Martorelli, Katy Mastorci, Elena Muraro, Jessica Dal Col, Giovanni Franchin, Luigi Barzan, Elisa Comaro, Emanuela Vaccher, Antonio Rosato and Riccardo Dolcetti

  Cancer Immunol Res May 1 2016 4 (5) 431-440; DOI:10.1158/2326-6066.CIR-15-0108

  
  

  Adoptive T-cell immunotherapy induces some responses in patients with nasopharyngeal carcinoma, but specificities are limited. A simple protocol is described that generates highly effective specific T cells, which could make adoptive immunotherapy more widely applicable.

• Research Articles

  Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice

  Andrea Sobo-Vujanovic, Lazar Vujanovic, Albert B. DeLeo, Fernando Concha-Benavente, Robert L. Ferris, Yan Lin and Nikola L. Vujanovic

  Cancer Immunol Res May 1 2016 4 (5) 441-451; DOI:10.1158/2326-6066.CIR-15-0104

  
  

  The role of soluble TNF in tumorigenesis, distinct from transmembrane TNF, was delineated. Soluble TNF promoted chemically induced carcinogenesis and mediated the expansion of myeloid-derived suppressor cells. This pathway could serve as a potential target for cancer prevention and therapy.

• Research Articles

  Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti–PD-L1 Immune Checkpoint Inhibitor

  Amanda J. Vandeveer, Jonathan K. Fallon, Robert Tighe, Helen Sabzevari, Jeffrey Schlom and John W. Greiner

  Cancer Immunol Res May 1 2016 4 (5) 452-462; DOI:10.1158/2326-6066.CIR-15-0176

  
  

  In an orthotopic model of non-muscle invasive bladder cancer, in which BCG had minimal activity, systemic administration of the anti–PD-L1 checkpoint inhibitor avelumab demonstrated durable antitumor responses and long-term survival mediated by CD4 and CD8 T cells.

• Research Articles

  Neoantigen Load, Antigen Presentation Machinery, and Immune Signatures Determine Prognosis in Clear Cell Renal Cell Carcinoma

  Hirokazu Matsushita, Yusuke Sato, Takahiro Karasaki, Tohru Nakagawa, Haruki Kume, Seishi Ogawa, Yukio Homma and Kazuhiro Kakimi

  Cancer Immunol Res May 1 2016 4 (5) 463-471; DOI:10.1158/2326-6066.CIR-15-0225

  
  

  In ccRCC the abundant neoepitopes associated with more effective antitumor immune responses were counterbalanced by a strongly immunosuppressive microenvironment. Therefore, combining blockade of immunosuppressive molecular pathways with immunotherapies targeting neoantigens may achieve synergistic antitumor activity.