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Abstract PR09: Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming

Mary Philip, Lauren Fairchild, Liping Sun, Agnes Viale, Steven Camara, Ellen Horste, Taha Merghoub, Jedd D. Wolchok, Christina S. Leslie and Andrea Schietinger
Mary Philip
Memorial Sloan Kettering Cancer Center, New York, NY.
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Lauren Fairchild
Memorial Sloan Kettering Cancer Center, New York, NY.
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Liping Sun
Memorial Sloan Kettering Cancer Center, New York, NY.
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Agnes Viale
Memorial Sloan Kettering Cancer Center, New York, NY.
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Steven Camara
Memorial Sloan Kettering Cancer Center, New York, NY.
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Ellen Horste
Memorial Sloan Kettering Cancer Center, New York, NY.
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Taha Merghoub
Memorial Sloan Kettering Cancer Center, New York, NY.
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Jedd D. Wolchok
Memorial Sloan Kettering Cancer Center, New York, NY.
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Christina S. Leslie
Memorial Sloan Kettering Cancer Center, New York, NY.
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Andrea Schietinger
Memorial Sloan Kettering Cancer Center, New York, NY.
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DOI: 10.1158/2326-6066.IMM2016-PR09 Published November 2016
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Article Information

Volume 4, Issue 11 Supplement, pp. PR09

DOI 
https://doi.org/10.1158/2326-6066.IMM2016-PR09

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074

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©2016 American Association for Cancer Research.

Author Information

  1. Mary Philip,
  2. Lauren Fairchild,
  3. Liping Sun,
  4. Agnes Viale,
  5. Steven Camara,
  6. Ellen Horste,
  7. Taha Merghoub,
  8. Jedd D. Wolchok,
  9. Christina S. Leslie, and
  10. Andrea Schietinger
  1. Memorial Sloan Kettering Cancer Center, New York, NY.
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Cancer Immunology Research: 4 (11 Supplement)
November 2016
Volume 4, Issue 11 Supplement
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Abstract PR09: Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming
Mary Philip, Lauren Fairchild, Liping Sun, Agnes Viale, Steven Camara, Ellen Horste, Taha Merghoub, Jedd D. Wolchok, Christina S. Leslie and Andrea Schietinger
Cancer Immunol Res November 1 2016 (4) (11 Supplement) PR09; DOI: 10.1158/2326-6066.IMM2016-PR09

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Abstract PR09: Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming
Mary Philip, Lauren Fairchild, Liping Sun, Agnes Viale, Steven Camara, Ellen Horste, Taha Merghoub, Jedd D. Wolchok, Christina S. Leslie and Andrea Schietinger
Cancer Immunol Res November 1 2016 (4) (11 Supplement) PR09; DOI: 10.1158/2326-6066.IMM2016-PR09
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  • Abstract B170: Therapeutic implications of altered epigenetics and DNA damage responses in IDH2-mutated hematologic diseases
  • Abstract B197: Translational control in macrophages during inflammatory response
  • Abstract B200: Single-cell RNA-sequencing (ScRNA-seq) reveals broad heterogeneity among CD8 T-cells during chronic viral infection and identifies a critical role for CD4 help in promoting the differentiation of a potent cytotoxic CD8 T-cell subset
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Other Topics: Oral Presentations - Proffered Abstracts

  • Abstract PR02: Antigen delivery targeting tumor-infiltrating macrophages leads to eradication of tumor highly resistant to immune checkpoint inhibitors
  • Abstract PR15: Engineering phagocytic signaling
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