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Table of Contents

Editorial

  • Editorial
    Fresh Beginnings
    Philip D. Greenberg, Robert D. Schreiber and Linda J. Miller
    Cancer Immunol Res January 1 2016 4 (1) 1-2; DOI:10.1158/2326-6066.CIR-15-0304

Meeting Report

Cancer Immunology Miniatures

  • Cancer Immunology Miniatures
    Radiologic Heterogeneity in Responses to Anti–PD-1/PD-L1 Therapy in Metastatic Renal Cell Carcinoma
    Guillermo de Velasco, Katherine M. Krajewski, Laurence Albiges, Mark M. Awad, Joaquim Bellmunt, F. Stephen Hodi and Toni K. Choueiri
    Cancer Immunol Res January 1 2016 4 (1) 12-17; DOI:10.1158/2326-6066.CIR-15-0197

    The management of mRCC is being revolutionized by immune checkpoint inhibition. Patient response to anti–PD-1/PD-L1 agents is heterogeneous, and misleading CT scans might be common. Examples of five classes of patient responses and their images are presented and interpreted.

  • Cancer Immunology Miniatures
    Short Peptide Vaccine Induces CD4+ T Helper Cells in Patients with Different Solid Cancers
    Stefanie Gross, Volker Lennerz, Elisa Gallerani, Nicolas Mach, Steffen Böhm, Dagmar Hess, Lotta von Boehmer, Alexander Knuth, Adrian Ochsenbein, Ulrike Gnad-Vogt, Ulf Forssmann, Thomas Woelfel and Eckhart Kaempgen
    Cancer Immunol Res January 1 2016 4 (1) 18-25; DOI:10.1158/2326-6066.CIR-15-0105

    The possibility that short peptide vaccines induce antitumor CD4+ T-cell responses has been widely ignored. Peripheral blood from vaccinated patients revealed that short peptides often activate specific T helper cells, facilitating a strong combined CD4+ and CD8+ T-cell response.

Priority Brief

  • Priority Brief
    IL17A-Mediated Endothelial Breach Promotes Metastasis Formation
    Paulina Kulig, Sara Burkhard, Joanna Mikita-Geoffroy, Andrew L. Croxford, Nadine Hövelmeyer, Gabor Gyülvészi, Christian Gorzelanny, Ari Waisman, Lubor Borsig and Burkhard Becher
    Cancer Immunol Res January 1 2016 4 (1) 26-32; DOI:10.1158/2326-6066.CIR-15-0154

    IL17A and TH17 cells have been implicated in both tumor promotion and tumor protection. In this preclinical mouse study the IL17 produced by tumor-invading γδ T cells was found to promote transendothelial tumor invasion and lung metastasis.

Research Articles

  • Research Articles
    MicroRNA MIR21 and T Cells in Colorectal Cancer
    Kosuke Mima, Reiko Nishihara, Jonathan A. Nowak, Sun A. Kim, Mingyang Song, Kentaro Inamura, Yasutaka Sukawa, Atsuhiro Masuda, Juhong Yang, Ruoxu Dou, Katsuhiko Nosho, Hideo Baba, Edward L. Giovannucci, Michaela Bowden, Massimo Loda, Marios Giannakis, Adam J. Bass, Glenn Dranoff, Gordon J. Freeman, Andrew T. Chan, Charles S. Fuchs, Zhi Rong Qian and Shuji Ogino
    Cancer Immunol Res January 1 2016 4 (1) 33-40; DOI:10.1158/2326-6066.CIR-15-0084

    Colon and rectal cancer cases in two U.S. nationwide prospective cohort studies were examined for an association of microRNA MIR21 (miR-21) and T-cell infiltration. MIR21 expression was inversely associated with densities of CD3+ and CD45RO+ T cells.

  • Research Articles
    Validation of Intratumoral T-bet+ Lymphoid Cells as Predictors of Disease-Free Survival in Breast Cancer
    Anna Marie Mulligan, Dushanthi Pinnaduwage, Sandrine Tchatchou, Shelley B. Bull and Irene L. Andrulis
    Cancer Immunol Res January 1 2016 4 (1) 41-48; DOI:10.1158/2326-6066.CIR-15-0051

    T-bet+ lymphoid cells are associated with adverse clinicopathologic features like the basal subgroup, yet confer a favorable outcome in invasive breast cancer. Thus, T-bet may prove to be an important prognostic and/or predictive marker for use in immunotherapy trials.

  • Research Articles
    Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models
    Peter R. Rhode, Jack O. Egan, Wenxin Xu, Hao Hong, Gabriela M. Webb, Xiaoyue Chen, Bai Liu, Xiaoyun Zhu, Jinghai Wen, Lijing You, Lin Kong, Ana C. Edwards, Kaiping Han, Sixiang Shi, Sarah Alter, Jonah B. Sacha, Emily K. Jeng, Weibo Cai and Hing C. Wong
    Cancer Immunol Res January 1 2016 4 (1) 49-60; DOI:10.1158/2326-6066.CIR-15-0093-T

    IL15 stimulates T-cell and NK-cell responses, but not Tregs. The antitumor efficacy, biodistribution, and toxicity of an IL15-based superagonist, ALT-803, was examined in animal models and was superior, supporting its clinical development for advanced hematologic or solid tumors.

  • Research Articles
    T-cell Exhaustion in Multiple Myeloma Relapse after Autotransplant: Optimal Timing of Immunotherapy
    David J. Chung, Katherine B. Pronschinske, Justin A. Shyer, Sneh Sharma, Samantha Leung, Shane A. Curran, Alexander M. Lesokhin, Sean M. Devlin, Sergio A. Giralt and James W. Young
    Cancer Immunol Res January 1 2016 4 (1) 61-71; DOI:10.1158/2326-6066.CIR-15-0055

    Autologous transplantation prolongs disease-free survival in multiple myeloma but is not curative. Regulatory T cells decline early after transplant, and T-cell exhaustion/senescence signals imminent relapse, providing therapeutic opportunities to revive antimyeloma immunity and counteract relapse.

  • Research Articles | AuthorChoice
    Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer
    Daniel S. Peiffer, Li-Shu Wang, Noah P. Zimmerman, Benjamin W.S. Ransom, Steven G. Carmella, Chieh-Ti Kuo, Jo-Hsin Chen, Kiyoko Oshima, Yi-Wen Huang, Stephen S. Hecht and Gary D. Stoner
    Cancer Immunol Res January 1 2016 4 (1) 72-82; DOI:10.1158/2326-6066.CIR-15-0091

    Black raspberries and their constituents effectively reduce carcinogen-induced tumorigenesis in the rat esophagus through the reduction of inflammation. Current findings show that these changes are associated with altered immune cell trafficking within the esophagus tissue as well.

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Cancer Immunology Research: 4 (1)
January 2016
Volume 4, Issue 1

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