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Cancer Immunology Research
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STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients

Raghvendra M. Srivastava, Sumita Trivedi, Fernando Concha-Benavente, Jie Hyun-bae, Lin Wang, Raja R. Seethala, Barton F. Branstetter IV, Soldano Ferrone and Robert L. Ferris
Raghvendra M. Srivastava
1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Sumita Trivedi
1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Fernando Concha-Benavente
2Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Jie Hyun-bae
1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Lin Wang
1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Raja R. Seethala
3Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Barton F. Branstetter IV
4Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
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Soldano Ferrone
5Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
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Robert L. Ferris
1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
2Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
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  • For correspondence: ferrisrl@upmc.edu
DOI: 10.1158/2326-6066.CIR-15-0053 Published August 2015
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ARTICLE USAGE: May 2015 to April 2021

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Total225116701154

Cited By

Article Information

Volume 3, Issue 8, pp. 936-945

DOI 
https://doi.org/10.1158/2326-6066.CIR-15-0053
PubMed 
25972070

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Received February 24, 2015
  • Revision received April 6, 2015
  • Accepted April 20, 2015
  • Published first May 13, 2015.

Article Versions

  • Previous version (May 13, 2015 - 11:23).
  • Previous version (July 9, 2015 - 06:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Raghvendra M. Srivastava1,
  2. Sumita Trivedi1,
  3. Fernando Concha-Benavente2,
  4. Jie Hyun-bae1,
  5. Lin Wang1,
  6. Raja R. Seethala3,
  7. Barton F. Branstetter IV4,
  8. Soldano Ferrone5, and
  9. Robert L. Ferris1,2,6,*
  1. 1Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  2. 2Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  3. 3Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  4. 4Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  5. 5Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  6. 6Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
  1. ↵*Corresponding Author:
    Robert L. Ferris, University of Pittsburgh, Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Room 2.26b, Pittsburgh, PA 15213. Phone: 412-623-0327; Fax: 412-623-4840; E-mail: ferrisrl{at}upmc.edu
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Cancer Immunology Research: 3 (8)
August 2015
Volume 3, Issue 8
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STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients
Raghvendra M. Srivastava, Sumita Trivedi, Fernando Concha-Benavente, Jie Hyun-bae, Lin Wang, Raja R. Seethala, Barton F. Branstetter IV, Soldano Ferrone and Robert L. Ferris
Cancer Immunol Res August 1 2015 (3) (8) 936-945; DOI: 10.1158/2326-6066.CIR-15-0053

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STAT1-Induced HLA Class I Upregulation Enhances Immunogenicity and Clinical Response to Anti-EGFR mAb Cetuximab Therapy in HNC Patients
Raghvendra M. Srivastava, Sumita Trivedi, Fernando Concha-Benavente, Jie Hyun-bae, Lin Wang, Raja R. Seethala, Barton F. Branstetter IV, Soldano Ferrone and Robert L. Ferris
Cancer Immunol Res August 1 2015 (3) (8) 936-945; DOI: 10.1158/2326-6066.CIR-15-0053
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