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Cancer Immunology Research
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Cancer Immunology at the Crossroads: Engineering

Engineering New Approaches to Cancer Vaccines

Naveen K. Mehta, Kelly D. Moynihan and Darrell J. Irvine
Naveen K. Mehta
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Kelly D. Moynihan
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
3Ragon Institute of MGH, MIT and Harvard University, Boston, Massachusetts.
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Darrell J. Irvine
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
3Ragon Institute of MGH, MIT and Harvard University, Boston, Massachusetts.
4Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
5Howard Hughes Medical Institute, Chevy Chase, Maryland.
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  • For correspondence: djirvine@mit.edu
DOI: 10.1158/2326-6066.CIR-15-0112 Published August 2015
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Article Information

Volume 3, Issue 8, pp. 836-843

DOI 
https://doi.org/10.1158/2326-6066.CIR-15-0112
PubMed 
26156157

Published By 
American Association for Cancer Research
Print ISSN 
2326-6066
Online ISSN 
2326-6074
History 
  • Published first July 8, 2015.

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  • Previous version (July 8, 2015 - 06:52).
  • Previous version (July 10, 2015 - 13:45).
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Copyright & Usage 
©2015 American Association for Cancer Research.

Author Information

  1. Naveen K. Mehta1,2,
  2. Kelly D. Moynihan1,2,3, and
  3. Darrell J. Irvine1,2,3,4,5,*
  1. 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  2. 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  3. 3Ragon Institute of MGH, MIT and Harvard University, Boston, Massachusetts.
  4. 4Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  5. 5Howard Hughes Medical Institute, Chevy Chase, Maryland.
  1. ↵*Corresponding Author:
    Darrell J. Irvine, MIT, MIT Room 76-261, 77 Massachusetts Avenue, Cambridge, MA 02139. Phone: 617-452-4174; Fax: 617-452-3293; E-mail: djirvine{at}mit.edu
  1. N.K. Mehta and K.D. Moynihan contributed equally to this article.

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Cancer Immunology Research: 3 (8)
August 2015
Volume 3, Issue 8
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Engineering New Approaches to Cancer Vaccines
Naveen K. Mehta, Kelly D. Moynihan and Darrell J. Irvine
Cancer Immunol Res August 1 2015 (3) (8) 836-843; DOI: 10.1158/2326-6066.CIR-15-0112

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Engineering New Approaches to Cancer Vaccines
Naveen K. Mehta, Kelly D. Moynihan and Darrell J. Irvine
Cancer Immunol Res August 1 2015 (3) (8) 836-843; DOI: 10.1158/2326-6066.CIR-15-0112
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    • Abstract
    • Motivation for Cancer Vaccine Engineering
    • Targeting Vaccines to Lymph Nodes
    • Vaccine-Mediated Programming of T-cell Homing to Tumor Sites
    • Exploiting the Tumor Site as an Antigen Source
    • Active Depots with Implantable Vaccine Scaffolds
    • Conclusions
    • Disclosure of Potential Conflicts of Interest
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