Table of Contents

Research Articles

• Research Articles

  Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer

  Shiro Kibe, Shigeru Yutani, Satoru Motoyama, Takanobu Nomura, Natsuki Tanaka, Akihiko Kawahara, Tomohiko Yamaguchi, Satoko Matsueda, Nobukazu Komatsu, Masatomo Miura, Yudai Hinai, Satoshi Hattori, Akira Yamada, Masayoshi Kage, Kyogo Itoh, Yoshito Akagi and Tetsuro Sasada

  Cancer Immunol Res December 1 2014 2 (12) 1154-1162; DOI:10.1158/2326-6066.CIR-14-0035

  
  

  Kibe and colleagues report the safety and benefit in a phase II study of 60 pretreated, advanced colorectal cancer (CRC) patients of personalized vaccines comprising HLA-matched peptides selected from preexisting host immunity, providing a new approach of personalized immunotherapy for refractory CRC.
• Research Articles

  Intravenous Injection of MVA Virus Targets CD8⁺ Lymphocytes to Tumors to Control Tumor Growth upon Combinatorial Treatment with a TLR9 Agonist

  Laetitia Fend, Tanja Gatard-Scheikl, Jacqueline Kintz, Murielle Gantzer, Emmanuelle Schaedler, Karola Rittner, Sandrine Cochin, Sylvie Fournel and Xavier Préville

  Cancer Immunol Res December 1 2014 2 (12) 1163-1174; DOI:10.1158/2326-6066.CIR-14-0050

  
  

  Fend and colleagues show in an orthotopic mouse model of renal carcinoma that intravenous and not subcutaneous injection of an MVA-MUC1 vaccine with TLR9 ligand (ODN1826) controls tumor growth by efficiently targeting tumor-specific effector/memory lymphocytes to the tumor.
• Research Articles

  Splenectomy Promotes Indirect Elimination of Intraocular Tumors by CD8⁺ T Cells That Is Associated with IFNγ- and Fas/FasL-Dependent Activation of Intratumoral Macrophages

  Maxine R. Miller, Jonathan B. Mandell, Kelly M. Beatty, Stephen A.K. Harvey, Michael J. Rizzo, Dana M. Previte, Stephen H. Thorne and Kyle C. McKenna

  Cancer Immunol Res December 1 2014 2 (12) 1175-1185; DOI:10.1158/2326-6066.CIR-14-0093-T

  
  

  Miller and colleagues demonstrate a mechanism by which splenectomy promotes rejection of intraocular tumors, which involves an IFNg-and-Fas/FasL-dependent interaction between CD8⁺ T cells and intratumoral macrophages eliciting severe ocular inflammation that indirectly eliminates intraocular tumors by inducing phthsis.
• Research Articles

  c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity

  Joseph C. Murray, Dalal Aldeghaither, Shangzi Wang, Rochelle E. Nasto, Sandra A. Jablonski, Yong Tang and Louis M. Weiner

  Cancer Immunol Res December 1 2014 2 (12) 1186-1198; DOI:10.1158/2326-6066.CIR-14-0083

  
  

  Murray and colleagues used RNAi functional genomics screening of 60 genes from an EGFR gene network and identified that inhibition of c-Abl activity in anti-EGFR-targeted cells can enhance the therapeutic efficacy of cetuximab, an ADCC-promoting anti-EGFR antibody, in colorectal and head and neck cancers.
• Research Articles

  STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment

  Takayuki Ohkuri, Arundhati Ghosh, Akemi Kosaka, Jianzhong Zhu, Maki Ikeura, Michael David, Simon C. Watkins, Saumendra N. Sarkar and Hideho Okada

  Cancer Immunol Res December 1 2014 2 (12) 1199-1208; DOI:10.1158/2326-6066.CIR-14-0099

  
  

  Ohkuri, Ghosh, Kosaka, and colleagues show that a STING-mediated DNA-sensor signaling is involved in IFN induction in the sterile microenvironment of brain tumor that enhances antitumor immunity, providing a proof-of-concept for developing STING agonists for cancer immunotherapy.
• Research Articles | AuthorChoice

  Granulin–Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity

  Phyllis F.Y. Cheung, Chi Wai Yip, Nicholas C.L. Wong, Daniel Y.T. Fong, Linda W.C. Ng, Angus M.Y. Wan, Chun Kwok Wong, Tan To Cheung, Irene O.L. Ng, Ronnie T.P. Poon, Sheung Tat Fan and Siu Tim Cheung

  Cancer Immunol Res December 1 2014 2 (12) 1209-1219; DOI:10.1158/2326-6066.CIR-14-0096

  
  

  Cheung and colleagues show that hepatic oncofetal protein granulin–epithelin precursor (GEP) regulates HCC immunity by modulating MICA and HLA-E expression, which could be reversed by GEP blockade; serum GEP and MICA levels are prognostic and can be used to stratify patients for targeted therapy.
• Research Articles

  Prognostic Impact of Human Leukocyte Antigen Class I Expression and Association of Platinum Resistance with Immunologic Profiles in Epithelial Ovarian Cancer

  Tasuku Mariya, Yoshihiko Hirohashi, Toshihiko Torigoe, Takuya Asano, Takafumi Kuroda, Kazuyo Yasuda, Masahito Mizuuchi, Tomoko Sonoda, Tsuyoshi Saito and Noriyuki Sato

  Cancer Immunol Res December 1 2014 2 (12) 1220-1229; DOI:10.1158/2326-6066.CIR-14-0101

  
  

  Mariya and colleagues analyzed 122 cases of epithelial ovarian cancer (EOC) and identified low expression of HLA class I and low intraepithelial CTL infiltration as independent prognostic factors for poor overall survival for patients with advanced EOC; low HLA class I expression was correlated with platinum resistance.
• Research Articles | AuthorChoice

  Functional TCR Retrieval from Single Antigen-Specific Human T Cells Reveals Multiple Novel Epitopes

  Petra Simon, Tana A. Omokoko, Andrea Breitkreuz, Lisa Hebich, Sebastian Kreiter, Sebastian Attig, Abdo Konur, Cedrik M. Britten, Claudia Paret, Karl Dhaene, Özlem Türeci and Ugur Sahin

  Cancer Immunol Res December 1 2014 2 (12) 1230-1244; DOI:10.1158/2326-6066.CIR-14-0108

  
  

  Simon, Omokoko, and colleagues developed an integrated approach to retrieve and functionally characterize TCRs from single viral or tumor Ag-reactive T cells and isolated 56 unique Ag-specific TCRs against 39 different epitopes, supporting rational design of T cell-based immunotherapies using this approach.