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Cancer Immunology Research
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Cancer Immunology at the Crossroads: Thoracic Oncology

Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer

Julie R. Brahmer and Drew M. Pardoll
Julie R. Brahmer
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
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Drew M. Pardoll
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
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DOI: 10.1158/2326-6066.CIR-13-0078 Published August 2013
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Abstract

Despite the limited success of immunotherapies in solid malignancy, two human cancers, melanoma and renal cancer, have, for many years, responded to systemic administration of immune-targeted biologics and showed signals of response to certain therapeutic vaccines. These findings underpinned a long-held perception that melanoma and renal cancer were uniquely “immunogenic” but that virtually all other human cancers were not and thus would not respond to immune modulation. That notion has now been shattered by the significant and durable responses in non–small cell lung cancer induced by therapeutic treatment with antibodies blocking the PD-1 checkpoint. The immunotherapy success in lung cancer thus provides a gateway to development of treatments for multiple cancer types that were previously believed not accessible to immune-based therapies. Cancer Immunol Res; 1(2); 85–91. ©2013 AACR.

  • Received June 20, 2013.
  • Accepted June 20, 2013.
  • ©2013 American Association for Cancer Research.
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Cancer Immunology Research: 1 (2)
August 2013
Volume 1, Issue 2
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Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer
Julie R. Brahmer and Drew M. Pardoll
Cancer Immunol Res August 1 2013 (1) (2) 85-91; DOI: 10.1158/2326-6066.CIR-13-0078

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Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer
Julie R. Brahmer and Drew M. Pardoll
Cancer Immunol Res August 1 2013 (1) (2) 85-91; DOI: 10.1158/2326-6066.CIR-13-0078
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    • Immune Resistance Mechanisms in Lung Cancer
    • CTLA-4 Inhibitors in Lung Cancer
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    • The Future: Beyond Single-Agent Immunotherapy
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Cancer Immunology Research
eISSN: 2326-6074
ISSN: 2326-6066

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