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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
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From the Current Issue

  • Research Articles
    A Genetic Screen to Identify Gain- and Loss-of-Function Modifications that Enhance T-cell Infiltration into Tumors
    Laura M. Rogers, Zhaoming Wang, Sarah L. Mott, Adam J. Dupuy and George J. Weiner
    Cancer Immunol Res September 1 2020 8 (9) 1206-1214; DOI:10.1158/2326-6066.CIR-20-0056

    An in vivo screen with the ability to induce gain-of-function mutations identifies genes that may enhance T-cell trafficking into tumors. These represent candidate targets that could be altered to enhance intratumoral trafficking of adoptively transferred T cells.

  • Research Articles | AuthorChoice
    Chemotherapeutic Tumor Microparticles Elicit a Neutrophil Response Targeting Malignant Pleural Effusions
    Pingwei Xu, Ke Tang, Jingwei Ma, Huafeng Zhang, Dianheng Wang, Liyan Zhu, Jie Chen, Keke Wei, Jincheng Liu, Haiqing Fang, Liang Tang, Yi Zhang, Jing Xie, Yuying Liu, Rui Meng, Li Liu, Xiaorong Dong, Kunyu Yang, Gang Wu, Fei Ma and Bo Huang
    Cancer Immunol Res September 1 2020 8 (9) 1193-1205; DOI:10.1158/2326-6066.CIR-19-0789

    Tumor cell–derived microparticles packaging a chemotherapeutic agent can induce neutrophil responses, which contribute to tumor killing and malignant pleural effusion (MPE) reduction. The data suggest that the microparticles could be a potential MPE therapy in patients.

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