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Cancer Immunology Research

Cancer Immunology Research

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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.

 

At the Crossroads: COVID-19 and Immune Checkpoint Blockade for Cancer, Chiara Garassino and Antoni Ribas.

  • CIR Current Cover
    Read the March issue!
    About the cover: Wagner et al, show that CAR T cells targeting the EDB splice variant of fibronectin, have potent antitumor activity in preclinical solid tumor models. Find out more in the article. Original image from Supplementary Fig. S14.
  • Cancer Immunology at the Crossroads
    Cancer Immunology at the Crossroads
    Read: Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy, Robert D. Leone, et al.
  • Perspective
    Perspective
    Read: At the Crossroads: COVID-19 and Immune-Checkpoint Blockade for Cancer, Marina Chiara Garassino, et al.
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From the Current Issue

  • What We're Reading
    A Sampling of Highlights from the Literature
    Cancer Immunol Res March 1 2021 9 (3) 253-253;

  • Research Articles
    The IKZF1–IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages
    Dimitrios Mougiakakos, Christian Bach, Martin Böttcher, Fabian Beier, Linda Röhner, Andrej Stoll, Michael Rehli, Claudia Gebhard, Christopher Lischer, Martin Eberhardt, Julio Vera, Maike Büttner-Herold, Katrin Bitterer, Heidi Balzer, Magdalena Leffler, Simon Jitschin, Michael Hundemer, Mohamed H.S. Awwad, Martin Busch, Steffen Stenger, Simon Völkl, Christian Schütz, Jan Krönke, Andreas Mackensen and Heiko Bruns
    Cancer Immunol Res March 1 2021 9 (3) 265-278; DOI:10.1158/2326-6066.CIR-20-0555

    Lenalidomide treatment for multiple myeloma skews M2-like macrophages to an M1 phenotype because lenalidomide triggers IKZF1 degradation, increasing IRF5 expression and decreasing IRF4. Modulating IKZF1 levels might provide a way to control macrophage polarization for cancer treatment.

  • Research Articles
    ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity
    Brian B. Haines, Agnieszka Denslow, Peter Grzesik, Jennifer S. Lee, Terry Farkaly, Jacqueline Hewett, Daniel Wambua, Lingxin Kong, Prajna Behera, Judith Jacques, Caitlin Goshert, Michael Ball, Allison Colthart, Mitchel H. Finer, Melissa W. Hayes, Sonia Feau, Edward M. Kennedy, Lorena Lerner and Christophe Quéva
    Cancer Immunol Res March 1 2021 9 (3) 291-308; DOI:10.1158/2326-6066.CIR-20-0609

    ONCR-177 is a next-generation oncolytic virus being tested in the clinic. Preclinical efficacy and safety are reported and highlight the treatment's use as a single-agent, as well as in combination with immune checkpoint blockade.

OnlineFirst Articles

  • Transient CD4 depletion induces remodeling of TCR repertoire
    Hiroyasu Aoki, et al.
  • γδ T cells in Merkel cell carcinomas
    Nicholas A Gherardin, et al.
  • Therapy sequencing in melanoma
    Manali S. Phadke, et al.
  • KIT signaling and type I interferon
    Mengyuan Liu, et al.
Load more

Trending - Altmetric

  • Article has an altmetric score of 52
    Targeted therapy given after anti-PD-1 leads to prolonged responses in mouse melanoma models through sustained antitumor immunity
    Last mentioned on Thu Mar 04 2021
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    Modified Hypoxia-Inducible Factor Expression in CD8+ T Cells Increases Antitumor Efficacy
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    Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
    Last mentioned on Thu Feb 25 2021
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    The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
    Last mentioned on Fri Feb 05 2021
  • Article has an altmetric score of 21
    pVACtools: a computational toolkit to identify and visualize cancer neoantigens
    Last mentioned on Wed Feb 17 2021
  • See more
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Cancer Immunology Research
eISSN: 2326-6074
ISSN: 2326-6066

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