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Read the December issue!
About the cover: Karamitopoulou et al. use an automated system to analyze the tumor microenvironment (TME) from patients with microsatellite-stable (MSS) and -instable (MSI) PDAC. Original image from Fig. 4. Artwork by Lewis Long.
In the Spotlight
Read: Exosomal lncRNA-Mediated Intercellular Communication Promotes Glioblastoma Chemoresistance, Weixi Zhao, et al.
Research Article
Read: PD-1/PD-L1–Associated Immunoarchitectural Patterns Stratify Pancreatic Cancer Patients into Prognostic/Predictive Subgroups, Eva Karamitopoulou, et al.
Review
Read: Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited, Chenfeng Han, et al.

From the Current Issue

What We're Reading

A Sampling of Highlights from the Literature

Cancer Immunol Res December 1 2021 9 (12) 1371-1371; DOI:10.1158/2326-6066.CIR-9-12-WWR
Research Articles

Glioblastoma Cell–Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance

Ziwei Li, Xiangqi Meng, Pengfei Wu, Caijun Zha, Bo Han, Lulu Li, Nan Sun, Tengfei Qi, Jie Qin, Yangong Zhang, Kaifu Tian, Shupeng Li, Changxiao Yang, Lejia Ren, Jianguang Ming, Pandeng Wang, Yifei Song, Chuanlu Jiang and Jinquan Cai

Cancer Immunol Res December 1 2021 9 (12) 1383-1399; DOI:10.1158/2326-6066.CIR-21-0258

The authors find glioblastoma cells transfer the long noncoding RNA lnc-TALC to microglia via exosomes. Lnc-TALC activates an ENO1/p38 MAPK pathway that results in C5 production, which promotes chemotherapy resistance. The data identify novel therapeutic strategies for glioblastoma.
Research Articles

Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets

Aude-Hélène Capietto, Seunghyun Lee, David Clever, Emily Eul, Haley Ellis, Cynthia X. Ma and Roberta Faccio

Cancer Immunol Res December 1 2021 9 (12) 1400-1412; DOI:10.1158/2326-6066.CIR-21-0232

Established tumors in bone can be refractory to osteoclast blockade and are protected from chemotherapeutic agents. The data highlight that bone metastases can be effectively treated by combining osteoclast blockade and anti-Gr1 to deplete Gr1⁺ cell subsets.
Research Articles

CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D. Kaiser and Emmanuel Donnadieu

Cancer Immunol Res December 1 2021 9 (12) 1425-1438; DOI:10.1158/2326-6066.CIR-20-0837

An IFNγ- and ICAM-1–dependent mechanism is used by CAR T cells to infiltrate tumors. The data provide a deeper understanding of CAR T-cell biology that can be used to improve treatment efficacy.