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Cancer Immunology Research

Cancer Immunology Research

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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.

 

At the Crossroads: COVID-19 and Immune Checkpoint Blockade for Cancer, Chiara Garassino and Antoni Ribas.

  • CIR Current Cover
    Read the January issue!
    About the cover: The study by Väyrynen et al. highlights the importance of utilizing multiplex analysis to more accurately determine the prognostic value of immune-cell subsets. Read more in the article. Artwork by Lewis Long.
  • Cancer Immunology at the Crossroads
    Cancer Immunology at the Crossroads
    Read: Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?, Zhibin Zhang, et al.
  • Research Article
    Research Article
    Read: CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function, Justin C. Boucher, et al.
  • Research Article
    Research Article
    Read: A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell–Mediated Antitumor Responses in Human B-cell Malignancies, Iris de Weerdt, et al.
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From the Current Issue

  • What We're Reading
    A Sampling of Highlights from the Literature
    Cancer Immunol Res January 1 2021 9 (1) 1-1;

  • Research Articles
    Activin A Promotes Regulatory T-cell–Mediated Immunosuppression in Irradiated Breast Cancer
    Mara De Martino, Camille Daviaud, Julie M. Diamond, Jeffrey Kraynak, Amandine Alard, Silvia C. Formenti, Lance D. Miller, Sandra Demaria and Claire Vanpouille-Box
    Cancer Immunol Res January 1 2021 9 (1) 89-102; DOI:10.1158/2326-6066.CIR-19-0305

    Activin A and TGFβ can shape the breast cancer tumor microenvironment after radiotherapy. Dual blockade of activin A and TGFβ reverses radiotherapy-induced Treg increases and boosts antitumor responses, highlighting potential targetable factors for breast cancer treatment.

  • Research Articles | AuthorChoice
    The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma
    Xiuli Wang, Christian Huynh, Ryan Urak, Lihong Weng, Miriam Walter, Laura Lim, Vibhuti Vyas, Wen-Chung Chang, Brenda Aguilar, Alfonso Brito, Aniee Sarkissian, N. Achini Bandara, Lu Yang, Jinhui Wang, Xiwei Wu, Jianying Zhang, Saul J. Priceman, Hong Qin, Larry W. Kwak, Lihua E. Budde, Sandra H. Thomas, Mary C. Clark, Leslie Popplewell, Tanya Siddiqi, Christine E. Brown and Stephen J. Forman
    Cancer Immunol Res January 1 2021 9 (1) 75-88; DOI:10.1158/2326-6066.CIR-20-0236

    In the clinic, CD19-CAR T cells are administered IV and are not used specifically to treat CNS lymphoma. The authors show a single ICV infusion of CD19-CAR T cells completely eradicates both CNS and systemic lymphoma in mice.

  • Research Articles | AuthorChoice
    A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
    Si-Qi Liu, Alyssa Grantham, Casey Landry, Brian Granda, Rajiv Chopra, Srinivas Chakravarthy, Sabine Deutsch, Markus Vogel, Katie Russo, Katherine Seiss, William R. Tschantz, Tomas Rejtar, David A. Ruddy, Tiancen Hu, Kimberly Aardalen, Joel P. Wagner, Glenn Dranoff and Joseph A. D'Alessio
    Cancer Immunol Res January 1 2021 9 (1) 34-49; DOI:10.1158/2326-6066.CIR-20-0080

    A genome-wide CRISPR screen was developed to understand cancer cell–derived resistance mechanisms to CD3-bispecific antibodies. The screen identifies IFNγ signaling being pivotal for responsiveness to CD3 bispecifics, and deficiency in core fucosylation as causing resistance to the therapeutic flotetuzumab.

OnlineFirst Articles

  • Therapy to Engage, Expand, and Enable Antitumor Responses
    Kellsye P. Fabian, et al.
  • At the Crossroads: COVID-19 and Immune Checkpoint Blockade for Cancer
    Marina Chiara Garassino, Antoni Ribas
  • Nutlin-3a: An Immune-Checkpoint Activator for NK Cells in Neuroblastoma
    Irene Veneziani, et al.
  • CD47–SIRPα Checkpoint Controls CD18 Activation via Kindlin3
    Panagiota Bouti, et al.
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Trending - Altmetric

  • Article has an altmetric score of 75
    ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity
    Last mentioned on Wed Jan 20 2021
  • Article has an altmetric score of 12
    IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D
    Last mentioned on Thu Jan 21 2021
  • Article has an altmetric score of 11
    At the Crossroads: COVID-19 and Immune Checkpoint Blockade for Cancer
    Last mentioned on Wed Jan 20 2021
  • Article has an altmetric score of 16
    Combined Targeting of Costimulatory (OX40) and Coinhibitory (CTLA-4) Pathways Elicits Potent Effector T Cells Capable of Driving Robust Antitumor Immunity
    Last mentioned on Wed Jan 13 2021
  • Article has an altmetric score of 6
    The tumor microenvironment impairs Th1 IFNγ secretion through alternative splicing modifications of Irf1 pre-mRNA
    Last mentioned on Tue Jan 19 2021
  • See more
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Cancer Immunology Research
eISSN: 2326-6074
ISSN: 2326-6066

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