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From the Current Issue

  • Cancer Immunology Miniatures
    Tumor Mutation Burden and Structural Chromosomal Aberrations Are Not Associated with T-cell Density or Patient Survival in Acral, Mucosal, and Cutaneous Melanomas
    Jarem Edwards, Peter M. Ferguson, Serigne N. Lo, Inês Pires da Silva, Andrew J. Colebatch, Hansol Lee, Robyn P.M. Saw, John F. Thompson, Alexander M. Menzies, Georgina V. Long, Felicity Newell, John V. Pearson, Nicola Waddell, Nicholas K. Hayward, Peter A. Johansson, Graham J. Mann, Richard A. Scolyer, Umaimainthan Palendira and James S. Wilmott
    Cancer Immunol Res November 1 2020 8 (11) 1346-1353; DOI:10.1158/2326-6066.CIR-19-0835

    Analysis shows that TMB does not correlate with tumor immune infiltrates, including tumor-resident CD8+ T cells, in acral, mucosal, and cutaneous melanomas. The data indicate that TMB is not a significant driver of antitumor responses.

  • Priority Brief
    A DNA-Launched Nanoparticle Vaccine Elicits CD8+ T-cell Immunity to Promote In Vivo Tumor Control
    Ziyang Xu, Neethu Chokkalingam, Edgar Tello-Ruiz, Megan C. Wise, Mamadou A. Bah, Susanne Walker, Nicholas J. Tursi, Paul D. Fisher, Katherine Schultheis, Kate E. Broderick, Laurent Humeau, Daniel W. Kulp and David B. Weiner
    Cancer Immunol Res November 1 2020 8 (11) 1354-1364; DOI:10.1158/2326-6066.CIR-20-0061

    DNA nanoparticle vaccination plus electroporation robustly induces CD8+ CTL responses that are able to control, or protect from, melanoma growth in mice. The data demonstrate the utility of this platform and offer a strategy to boost antitumor responses.

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