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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
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Announcing our new Impact Factor: 11.151!

Read the September issue!
About the cover: Li, et al., find that the rate-limiting enzyme in 5-HT synthesis is upregulated in tumor tissues of mouse models, as well as patients with colorectal cancer. Find out more in the article. Artwork by Lewis Long.
In the Spotlight
Read, Fighting Liver Metastasis by Activating MAIT Cells, by Olivier Lantz.
Commentary
Read: Q&A: Lisa H. Butterfield, Elizabeth M. Jaffee, and Arlene H. Sharpe on the SITC–AACR Joint Workshop, “The Cancer Biology Underlying Immunotherapy-Induced Autoimmunity”
Research Article
Read: Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation, Tao Li, et al.

From the Current Issue

What We're Reading

A Sampling of Highlights from the Literature

Cancer Immunol Res September 1 2021 9 (9) 995-995; DOI:10.1158/2326-6066.CIR-9-9-WWR
Research Articles

Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response

Benjamin Ruf, Vanessa V. Catania, Simon Wabitsch, Chi Ma, Laurence P. Diggs, Qianfei Zhang, Bernd Heinrich, Varun Subramanyam, Linda L. Cui, Marie Pouzolles, Christine N. Evans, Raj Chari, Shunsuke Sakai, Sangmi Oh, Clifton E. Barry III, Daniel L. Barber and Tim F. Greten

Cancer Immunol Res September 1 2021 9 (9) 1024-1034; DOI:10.1158/2326-6066.CIR-20-0925

In vitro evidence suggests mucosal-associated invariant T (MAIT) cells can have antitumor function. This study shows MAIT cells stimulated in vivo using 5-OP-RU and CpG orchestrate potent antitumor responses, suggesting these cells as potential targets for cancer immunotherapy.
Research Articles

Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity

Reona Sakemura, Aditya Bansal, Elizabeth L. Siegler, Mehrdad Hefazi, Nan Yang, Roman H. Khadka, Alysha N. Newsom, Michael J. Hansen, Michelle J. Cox, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Erin E. Tapper, Wendy K. Nevala, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Paulina Horvei, Michael W. Ruff, Sameer A. Parikh, Mukesh K. Pandey, Timothy R. DeGrado, Lukkana Suksanpaisan, Neil E. Kay, Kah-Whye Peng, Stephen J. Russell and Saad S. Kenderian

Cancer Immunol Res September 1 2021 9 (9) 1035-1046; DOI:10.1158/2326-6066.CIR-20-0901

Currently, a robust imaging platform to monitor CART cells is lacking. Imaging using 18F-TFB-PET is demonstrated to be an efficient, noninvasive technique to monitor CART-cell expansion and trafficking in vivo in multiple tumor models.