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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.

 

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From the Current Issue

  • Cancer Immunology Miniatures
    In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
    Marius E. Mayerhoefer, Alexander Haug, Ulrich Jäger, Verena Pichler, Sarah Pfaff, Hans-Jürgen Wester, Marcus Hacker, Lukas Kazianka and Philipp B. Staber
    Cancer Immunol Res August 1 2020 8 (8) 984-989; DOI:10.1158/2326-6066.CIR-19-0880

    Ibrutinib is used to treat CLL. Labeling and imaging 9 patients with CLL show that in response to ibrutinib treatment, CXCR4+ CLL cells shift from lymph nodes and bone marrow to peripheral blood and the splenic cavernous system.

  • Research Articles
    The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth
    Siqi Chen, Imran Akdemir, Jie Fan, Joel Linden, Bin Zhang and Caglar Cekic
    Cancer Immunol Res August 1 2020 8 (8) 1064-1074; DOI:10.1158/2326-6066.CIR-19-0833

    Adenosine has pleiotropic effects in the tumor microenvironment. Adenosine A2B receptor expression on immunosuppressive antigen-presenting cells promotes tumor growth by inhibiting antitumor T cells. Blocking A2B receptor in combination with adoptive cell therapy induces profound antitumor effects.

  • Research Articles | AuthorChoice
    The Mincle/Syk/NF-κB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages
    Chunjie Li, Vivian Weiwen Xue, Qing-Ming Wang, Guang-Yu Lian, Xiao-Ru Huang, Tin-Lap Lee, Ka-Fai To, Patrick Ming-Kuen Tang and Hui-Yao Lan
    Cancer Immunol Res August 1 2020 8 (8) 1004-1017; DOI:10.1158/2326-6066.CIR-19-0782

    Macrophages in tumors can promote or hinder cancer progression. The expression of the pattern-recognition receptor Mincle on tumor-associated macrophages (TAMs) leads to the activation of the Syk/NF-κB pathway and subsequent establishment of protumoral TAMs.

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