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Read the July issue!
About the cover: Gomes-Santos, et al. demonstrate in murine models of breast cancer that exercise training contributes to tumor control and response to ICB. Find out more in the article. Original image from Fig. 2G. Artwork by Lewis Long.
In the Spotlight
Read: IL11: A Specific Repressor of Tumor-Specific CD4+ T Cells, Sjoerd H. van der Burg.
In the Spotlight
Read: Characterizing the Complexities of Neutrophils with Suppressive Properties, Marco Antonio Cassatella.

From the Current Issue

What We're Reading

A Sampling of Highlights from the Literature

Cancer Immunol Res July 1 2021 9 (7) 723-723;
Research Articles

Host IL11 Signaling Suppresses CD4⁺ T cell–Mediated Antitumor Responses to Colon Cancer in Mice

Jennifer Huynh, David Baloyan, David Chisanga, Wei Shi, Megan O'Brien, Shoukat Afshar-Sterle, Mariah Alorro, Lokman Pang, David S. Williams, Adam C. Parslow, Pathum Thilakasiri, Moritz F. Eissmann, Louis Boon, Frederick Masson, Ashwini L. Chand and Matthias Ernst

Cancer Immunol Res July 1 2021 9 (7) 735-747; DOI:10.1158/2326-6066.CIR-19-1023

This study shows genetic ablation of IL11 signaling augments production of IFNγ and TNFα by antitumor CD4⁺ T cells, suppressing colon cancer development in vivo. The data suggest IL11 as a potential therapeutic target in colon cancer.
Research Articles

Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

Tiffany R. Emmons, Thejaswini Giridharan, Kelly L. Singel, ANM Nazmul H. Khan, Jason Ricciuti, Kaitlyn Howard, Stephanie L. Silva-Del Toro, Ivy L. Debreceni, Cathelijn E.M. Aarts, Mieke C. Brouwer, Sora Suzuki, Taco W. Kuijpers, Ilse Jongerius, Lee-Ann H. Allen, Viviana P. Ferreira, Anna Schubart, Holger Sellner, Jörg Eder, Steven M. Holland, Sanjay Ram, James A. Lederer, Kevin H. Eng, Kirsten B. Moysich, Kunle Odunsi, Michael B. Yaffe, Emese Zsiros and Brahm H. Segal

Cancer Immunol Res July 1 2021 9 (7) 790-810; DOI:10.1158/2326-6066.CIR-20-0922

The ovarian cancer microenvironment induces suppressor neutrophils that inhibit T-cell signaling and metabolic functions. Acquisition of the suppressor phenotype is dependent on several pathways including complement signaling, which can be targeted therapeutically to enhance antitumor immunity.
Priority Brief

Regulatory T-cell Transcriptomic Reprogramming Characterizes Adverse Events by Checkpoint Inhibitors in Solid Tumors

Maria Grigoriou, Aggelos Banos, Aikaterini Hatzioannou, Andreas Kloetgen, Panagiotis Kouzis, Despoina Aggouraki, Roubini Zakopoulou, Giorgos Bamias, Eva Kassi, Dimitrios Mavroudis, Aristotelis Bamias, Dimitrios T. Boumpas, Aristotelis Tsirigos, Helen Gogas, Themis Alissafi and Panayotis Verginis

Cancer Immunol Res July 1 2021 9 (7) 726-734; DOI:10.1158/2326-6066.CIR-20-0969

Regulatory T cells (Treg) maintain peripheral tolerance. The authors show a common inflammatory signature between Tregs from patients with solid tumors who develop immune-related adverse events and Tregs from patients with autoimmune diseases, suggesting shared underlying mechanisms.