Table 1.

Established gene signatures indicative of a T cell–inflamed tumor microenvironment

Gene signatureGenes
Gajewski T cell–inflamed signature (13)IRF1, CD8A, CCL2, CCL3, CCL4, CXCL9, CXCL10, ICOS, GZMK, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB
IFNγ-related gene signature (11)CD8A, CCL5, CD27, CD274, PDCD1LG2, CD276, CMKLR1, CXCL9, CXCR6, HLA.DQA1, HLA.DRB1, HLA.E, IDO1, LAG3, NKG7, PSMB10, STAT1, TIGIT
T effector signature (81)GZMA, GZMB, PRF1, EOMES, IFNG, TNF, CXCL9, CXCL10, CD8A, CD4, FOXP3, ICOS, CTLA4
Immune cytolytic activity (82)GZMA, PRF