Fraction of PDCD1LG2-expressing tumor cells (quartile)^{a} | ||||||
---|---|---|---|---|---|---|

Total no. | 0%–20%, quartile 1 | 21%–50%, quartile 2 | 51%–80%, quartile 3 | 81%–100%, quartile 4 | P^{b} | |

Crohn-like lymphoid reaction (n = 680) | 0.0002 | |||||

Negative/low | 505 (74%) | 121 (66%) | 105 (71%) | 151 (76%) | 128 (84%) | |

Intermediate | 127 (19%) | 42 (23%) | 31 (21%) | 39 (20%) | 15 (10%) | |

High | 48 (7%) | 19 (10%) | 11 (7%) | 9 (5%) | 9 (6%) | |

Peritumoral lymphocytic reaction (n = 811) | 0.80 | |||||

Negative/low | 118 (15%) | 32 (15%) | 24 (13%) | 31 (13%) | 31 (18%) | |

Intermediate | 573 (71%) | 145 (70%) | 132 (71%) | 178 (74%) | 118 (67%) | |

High | 120 (15%) | 30 (14%) | 30 (16%) | 32 (13%) | 28 (16%) | |

Intratumoral periglandular reaction (n = 813) | 0.10 | |||||

Negative/low | 102 (13%) | 24 (12%) | 16 (9%) | 30 (12%) | 32 (18%) | |

Intermediate | 618 (76%) | 160 (77%) | 146 (78%) | 186 (77%) | 126 (71%) | |

High | 93 (11%) | 23 (11%) | 25 (13%) | 26 (11%) | 19 (11%) | |

TILs (n = 812) | 0.07 | |||||

Negative/low | 594 (73%) | 149 (72%) | 128 (69%) | 177 (73%) | 140 (79%) | |

Intermediate | 128 (16%) | 33 (16%) | 30 (16%) | 42 (17%) | 23 (13%) | |

High | 90 (11%) | 25 (12%) | 28 (15%) | 23 (10%) | 14 (8%) |

↵

^{a}Tumors were categorized into quartiles according to the percentage of PDCD1LG2–expressing carcinoma cells (quartile 1, 0%–20%; quartile 2, 21%–50%; quartile 3, 51%–80%; quartile 4, 81%–100%).↵

^{b}*P*value was calculated by Spearman correlation test between tumor PDCD1LG2 expression (ordinal quartile categories; 1–4) and each histologic pattern of lymphocytic reaction (ordinal categories; negative/low, intermediate, and high). Because we assessed four primary outcome variables, we adjusted two-sided α level to 0.01 (≈0.05/4) by simple Bonferroni correction.