Table 2.

Distribution of colorectal cancer cases according to tumor PDCD1LG2 (PD-L2) expression and histologic lymphocytic reaction patterns

Fraction of PDCD1LG2-expressing tumor cells (quartile)a
Total no.0%–20%, quartile 121%–50%, quartile 251%–80%, quartile 381%–100%, quartile 4Pb
Crohn-like lymphoid reaction (n = 680)0.0002
 Negative/low505 (74%)121 (66%)105 (71%)151 (76%)128 (84%)
 Intermediate127 (19%)42 (23%)31 (21%)39 (20%)15 (10%)
 High48 (7%)19 (10%)11 (7%)9 (5%)9 (6%)
Peritumoral lymphocytic reaction (n = 811)0.80
 Negative/low118 (15%)32 (15%)24 (13%)31 (13%)31 (18%)
 Intermediate573 (71%)145 (70%)132 (71%)178 (74%)118 (67%)
 High120 (15%)30 (14%)30 (16%)32 (13%)28 (16%)
Intratumoral periglandular reaction (n = 813)0.10
 Negative/low102 (13%)24 (12%)16 (9%)30 (12%)32 (18%)
 Intermediate618 (76%)160 (77%)146 (78%)186 (77%)126 (71%)
 High93 (11%)23 (11%)25 (13%)26 (11%)19 (11%)
TILs (n = 812)0.07
 Negative/low594 (73%)149 (72%)128 (69%)177 (73%)140 (79%)
 Intermediate128 (16%)33 (16%)30 (16%)42 (17%)23 (13%)
 High90 (11%)25 (12%)28 (15%)23 (10%)14 (8%)
  • aTumors were categorized into quartiles according to the percentage of PDCD1LG2–expressing carcinoma cells (quartile 1, 0%–20%; quartile 2, 21%–50%; quartile 3, 51%–80%; quartile 4, 81%–100%).

  • bP value was calculated by Spearman correlation test between tumor PDCD1LG2 expression (ordinal quartile categories; 1–4) and each histologic pattern of lymphocytic reaction (ordinal categories; negative/low, intermediate, and high). Because we assessed four primary outcome variables, we adjusted two-sided α level to 0.01 (≈0.05/4) by simple Bonferroni correction.