Table 2.

Sensitivity and specificity analysis of CT scans

CT/biopsyCT/corticosteroid
Subgroup
n3447
Sensitivity85.2%76.7%
Specificity75.0%88.2%
PPV95.8%92.0%
NPV42.9%68.2%
Positive likelihood ratio (LR+)3.36.5
Negative likelihood ratio (LR−)0.190.26
  • NOTE: Analysis of CT scan data in two groups. Biopsy group validated CT findings with colonoscopy and biopsy results from patients. Steroid treatment group validated CT findings with the need for patients to receive steroid treatment for resolution of ipilimumab-induced colitis symptoms.