Table 2.

Response rate stratified by mutational burden

ResponseNo responseP
Initial cohort (n = 32)
High (>23.1 mutations/MB), n = 119 (82%)2 (18%)0.003
Intermediate (3.3–23.1 mutations/MB), n = 114 (36%)7 (64%)
Low (<3.3 mutations/MB), n = 101 (10%)9 (90%)
Validation cohort (n = 33)
High (>23.1 mutations/MB), n = 1614 (88%)2 (12%)0.001
Intermediate (3.3–23.1 mutations/MB), n = 133 (23%)10 (77%)
Low (<3.3 mutations/MB), n = 41 (25%)3 (75%)
Entire cohort (n = 65)
High (>23.1 mutations/MB), n = 2723 (85%)4 (15%)<0.001
Intermediate (3.3–23.1 mutations/MB), n = 247 (29%)17 (71%)
Low (<3.3 mutations/MB), n = 142 (14%)12 (86%)