Table 3.

Altered genes in responders and nonresponders

Responders (n = 32)Nonresponders (N = 33)
GeneNumber (%)Number (%)P
BRAF V6005 (16)9 (27)0.25
BRAF non-V6003 (9)1 (3)0.29
NRAS5 (16)6 (18)0.78
NF116 (50)7 (21)0.02
“Triple WT”a4 (13)11 (33)0.05
TP539 (28)7 (21)0.57
MYC2 (6)4 (12)0.41
APC/CTNNB13 (9)2 (6)0.61
IGF1R/HGF4 (13)2 (6)0.37
PTEN4 (13)5 (15)0.76
CDKN2A/CDK4/CDK6/RB1 alterations14 (44)19 (58)0.27
LRP1B11 (34)1 (3)0.001
  • aBRAF, NRAS, NF1 wild-type.