Table 1.

Tumor-infiltrating CD8+ T-cell functional annotation clusters

DAVID clusterEnrichment scoreCluster descriptionNumber of genesSelected genes composing cluster
Upregulated in tumor CD8+ T cells
16.88Surface/plasma membrane58Pdcd1, Cd38, Ctla4, Ly6a, Adora3, Enpp5, Slc16a10, Itgav
72.65Negative regulation of cell signaling/G-protein regulation13Cish, Rgs1, Rgs3, Rgs16, Spry1, Spry2, Socs2, Tgfb3, Atxn1
82.52SH2 domain22Sh3bp2, Lyn, Chn2, Cish, Clnk, Grb7, Plcg2, Stat2, Vav3
142.61Ig-like domain23Cd7, Cd80, CD86, Cd160, Cd200r, Lag3, Havcr2,Tigit, Lilrb4
191.78Phosphatases12Dusp4, Dusp14, Ptpn5, Ptpn7, Ptpn9, Ptpn13, Ptprj, Inpp4a, Inpp4b, Impa2
Downregulated in tumor CD8+ T cells
13.06Transmembrane/receptor106Cd72, Gpr146, Cd163l1,Cxcr5, Ccr7, Itb3, Tnfrsf10b,Tbxa2r
31.78Cytokine receptor/receptor17Btla, CD22, Emb, Il4ra, Il6ra, Il6st, Il7r, Il18r1, Ifngr2
51.55Ig-like domain16Treml2, Slamf6, Emb, Fcgrt, Icam2, Sell, Pecam1, Sema4f
101.05Kinases/phosphorylation57Mapk11, Yes1, Dgka, Dusp10, Pik3r5, Ssh2, Stk38, Acp5