Table 1

WHO grade III and IV systemic side effects after TNF-based ILP.

Reference Year Treatment Combinationa No. of Patients Side Effect Observed (%)
Hypotension Lung Kidney Liver Blood
56 1994 TIM 53 1.7 17 1.7 12 7
57 1996 TIM 26 39 8 0 27 8
70 1996 TIM 59 1.6 1.6 1.6 12 7
61b 1999 TIM 32 9 3 0 0 0
61b 1999 TM 32 16 9 0 0 0

aAbbreviations: TIM, TNF/IFN-γ/melphalan; TM, TNF/melphalan. bRandomised phase II study in melanoma where a comparison of TIM with TM was made.