Table 2.

Associations between the proportion of each immune cell subset and PFS

Cell subsetsHR (95% CI)P value
Suppressor cells
 M-MDSCs3.4 (1.4–8.3)0.006
 Granulocytic MDSCs1.3 (0.6–2.9)0.5
 CD4+ FOXP3+1.4 (0.6–3.2)0.4
 Naïve Tregs0.9 (0.4–2.1)0.8
 Effector Tregs1.6 (0.7–3.5)0.3
Effector cells
 CD3+0.7 (0.3–1.6)0.4
 CD4+1.0 (0.5–2.3)1
  Naïve0.9 (0.4–2.1)0.9
  Central memory1.3 (0.6–3.0)0.5
  Effector memory0.3 (0.1–0.7)0.007
  Terminally differentiated effector0.6 (2.9–1.5)0.3
  Granzyme B+1.0 (0.4–2.1)1
  Perforin+1.3 (0.6–2.9)0.5
  Ki-67+1.6 (0.7–3.6)0.2
 CD8+0.4 (0.2–1.03)0.06
  Naïve0.7 (0.3–1.6)0.4
  Central memory1.5 (0.7–3.5)0.3
  Effector memory0.3 (0.1–0.6)0.004
  Terminally differentiated effector0.6 (0.3–1.5)0.3
  Granzyme B+0.5 (0.2–1.1)0.09
  Perforin+0.7 (0.3–1.5)0.3
  Ki-67+1.1 (0.5–2.5)0.8
 NK cell1.4 (0.6–3.1)0.4
Antigen-presenting cells
 Myeloid dendritic cells0.9 (0.4–1.9)0.7
 Plasmacytoid dendritic cells0.7 (0.3–1.6)0.4
  • NOTE: Patients were divided into high (>median) and low (<median) groups based on the median value of the proportion of each immune cell subset, and univariate analyses for PFS were performed by using Cox proportional hazards models. The reference for the HR is a low group of each immune cell subset.