Table 1.

Toxicity profiles

Number of patients (percentage) ≤ grade 2
ToxicitiesCohort 1Cohort 2Cohort 3Cohort 4Cohort 5Cohort 6
General disorders and administration site conditions1 (33.3%)1 (33.3%)1 (25%)3 (75%)
Asthenia3 (75%)
Fatigue1 (33.3%)1 (25%)1 (25%)
Chills1 (33.3%)a1 (25%)
Infections and infestations3 (75%)
Sweating/fever2 (50%)
Febrile infection1 (25%)
Nervous system disorders2 (50%)
Headache2 (50%)
Musculoskeletal and connective tissue disorder2 (50%)
Myalgia1 (25%)
  • aOnly this patient was assessed as having grade 2 toxicity; the others had grade 1 toxicity.