Table 1.

Patient and healthy donor characteristics

CharacteristicsIpilimumab 10 mg/kgIpilimumab 3 mg/kgHealthy donorsa
Number of patients284020
Median age (range)62 (34–83)60 (34–80)38 (26–58)
Sex (%)
 Male17 (61)29 (73)10 (50)
 Female11 (39)11 (27)7 (35)
Stage of disease (%)
 III (unresectable)01
 M1a30
 M1b45
 M1c2134
Median number of prior therapies (range)1 (0–3)1 (0–5)
 Median LDH (range)209 (113–968)211 (117–816)
 ≥Upper limit of normal (% of available LDH)13 (46)28 (70)
 <Upper limit of normal (% of available LDH)15 (54)12 (30)
MDSC frequency
 %HLA-DRlow/− in LinCD14+CD11b+ (range)b11.4 (3.9–24.5)11.2 (5.8–20.9)10.3 (6.4–14.3)
 ≥14.9 (%)7 (25)7 (18)0 (0)
 <14.9 (%)21 (75)33 (82)20 (100)
Median baseline ALC (range)1,250 (500–5,100)1,100 (600–8,100)
 ≥1,000/μL (%)19 (68)25 (63)
 <1,000/μL (%)9 (32)15 (37)
  • aData for anonymously donated blood bank samples are unavailable.

  • bBaseline values.