Table 1.

Tim-3 expression (percentage and MFI) according to demographic and clinical parameters with well-known prognostic value

Demographic and clinical parametersNumber of patients[N = 83 (%)]Tim-3+ cells (%)Mean (SD)PTim-3+ cells (MFI)Mean (SD)P
Age groups, ya0.41220.9363
 ≤4522 (27)71.77 (10.78)31.30 (5.953)
 46–7030 (36)69.51 (13.52)30.94 (6.650)
 ≥7131 (37)66.34 (18.15)30.62 (7.319)
Genderb0.75440.4382
 Female27 (33)69.19 (12.67)30.09 (6.630)
 Male56 (67)69.28 (15.85)31.31 (6.701)
Stagea0.21160.0114
 I47 (56)66.01 (15.78)29.07 (5.303)
 II18 (22)69.93 (17.45)32.39 (7.895)
 III/IV18 (22)73.28 (9.973)34.30 (8.479)
Thickness, mmb0.0410.0059
 ≤147 (57)66.03 (15.47)29.18 (5.642)
 >136 (43)72.70 (13.20)33.18 (7.166)
Mitotic indexb0.00560.0278
 <1/mm235 (42)65.01 (15.83)29.28 (5.771)
 ≥1/mm242 (51)73.54 (10.21)32.46 (6.540)
 Unclassified6 (7)
Ulcerationb0.03510.0466
 Absent58 (70)67.51 (15.34)30.19 (6.263)
 Present19 (23)75.58 (9.979)33.61 (6.811)
 Unclassified6 (7)
LN statusb0.32800.8242
 Negative70 (84)68.24 (15.58)30.85 (6.875)
 Positive13 (16)72.64 (9.389)31.30 (5.647)
Metastasisb0.14760.0092
 Absent74 (89)68.10 (15.22)30.26 (6.105)
 Present9 (11)75.70 (8.996)36.31 (8.840)

Abbreviation: LN, lymph node.

  • aOne-way ANOVA.

  • bUnpaired t test.