Autoimmune side effects are frequent in cancer patients treated with "immune checkpoint" targeting antibodies, but are rare with cancer vaccines. Here we report on a metastatic melanoma patient who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including the brain, the patient is alive and well more than 13 years after diagnosis of metastatic disease. The strongly activated tumor specific CD8+ T cells showed robust and long-term memory and effector functions. Possibly, long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as in this patient.
- Received August 4, 2014.
- Revision received September 1, 2014.
- Accepted September 14, 2014.
- Copyright © 2014, American Association for Cancer Research.