A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells. Ten years after, the patient remains in complete remission. Remarkable immunological correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-168 EADPTGHSY-specific CD8+ T-cells. While the induction of NY-ESO-1 antibody most likely resulted from gamma-knife mediated 'auto-vaccination', the persistence of circulating MAGE-A1 specific T-cells, which are still detectable ex-vivo in the absence of any tumor manifestation, coincide with DC-based vaccination administered until today.
- Received November 12, 2013.
- Revision received January 7, 2014.
- Accepted January 23, 2014.
- Copyright © 2014, American Association for Cancer Research.