The fourth AACR Special Conference “Tumor Immunology: Basic and Clinical Advances” was held in Miami, FL in November 2012. The overall objective of this meeting was to discuss emerging concepts in cancer immunology and immunotherapy. The key findings that emerged from this meeting included: (i) multiple immune checkpoints should be inhibited to increase effective T-cell therapy, (ii) successful adoptive T-cell therapy will rely on obtaining the proper T-cell phenotype, (iii) chimeric antigen receptors have shown promise in treating some B-cell malignancies, and (iv) multiple pathways of inflammation within the tumor microenvironment are immunotherapy targets. Cancer Immunol Res; 1–8. ©2013 AACR.
- Received February 12, 2013.
- Accepted February 13, 2013.
- ©2013 American Association for Cancer Research.