Masters of Immunology
Harold F. Dvorak
Cancer Immunol Res January 1 2015 3 (1) 1-11; DOI:10.1158/2326-6066.CIR-14-0209
Joseph and colleagues describe the immunemediated rash, lichenoid dermatitis, in three patients treated with anti–PD-1 (MK-3475). These mild rashes are characterized by a marked T-cell infiltrate with ∼10% PD-1+ T cells.
Matsushita and colleagues used microarray gene expression analysis coupled with fluorescent ubiquitination-based cell-cycle indicator (fucci) analysis and flow cytometry of a B16 murine model of melanoma to demonstrate that the predominant mechanism of CTL therapy in regulating tumor growth is via IFNγ-mediated cell-cycle arrest.
Acquavella, Clever, and colleagues show that IFNγ and TNFα synergize with vemurafenib to induce tumor growth arrest, supporting further study of the intersection between immunologic and oncogenic signaling in cancer cells and of treatment strategies combining vemurafenib and T-cell–based immunotherapy.
Heeren, Koster, and colleagues performed a comprehensive analysis of the immune-cell subsets and cytokine release profile in tumor-draining lymph nodes from patients with cervical cancer, providing information about the local immunosuppressive mechanisms that promote immune escape and metastatic spread.
Zhou and colleagues identify broad immune responses to ATP6S1 in the peripheral blood of patients with advanced melanoma; augmented humoral responses from ipilimumab treatment correlated with beneficial clinical outcomes, and the authors propose the development of ATP6S1 as a biomarker and therapeutic target.
Santoro and colleagues show that CAR T cells directed against the tumor vascular antigen, prostate-specific membrane antigen, directly killed and eliminated tumor endothelial cells in murine cancer models, providing a rationale for using CAR T cells for tumor vascular disruption.
Danelli and colleagues demonstrate interactions between mast cells and myeloid-derived suppressor cells in the mucosa of colon carcinoma patients and in the colon and spleen of tumor-bearing mice and establish the role of CD40/CD40L in the activity of these cells in colon cancer.